UniProt Q6PHU5
Sortilin (Q6PHU5)
Sortilin (UniProt Q6PHU5): 10 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6PHU5
- Protein
- Sortilin
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 46 · 3 records with a druggable one
Structures
11 records of Q6PHU5 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5NMR | Monomeric mouse Sortilin extracellular domain | x-ray diffraction | A | NAG, CA | — |
| 5NMR | Monomeric mouse sortilin extracellular domain | x-ray diffraction | A | NAG, CA | — |
| 5NMT | Dimer structure of Sortilin ectodomain crystal form 1, 2.3A | x-ray diffraction | A, B | NAG, CL | — |
| 5NMT | Dimer structure of sortilin ectodomain crystal form 1, 2.3A | x-ray diffraction | A, B | NAG, CL | — |
| 5NNI | Dimer structure of Sortilin ectodomain crystal form 2, 3.2 Angstrom | x-ray diffraction | A, B | NAG | — |
| 5NNI | Dimer structure of sortilin ectodomain crystal form 2, 3.2 ångström | x-ray diffraction | A, B | NAG | — |
| 5NNJ | Dimer structure of Sortilin ectodomain crystal form 3, 4.0 Angstrom | x-ray diffraction | A, B, D, C | NAG | 20 (best 0.71) |
| 5NNJ | Dimer structure of sortilin ectodomain crystal form 3, 4.0 ångström | x-ray diffraction | A, B, D, C | NAG | — |
| 5ZNN | Crystal structure of ligand-free form of the Vps10 ectodomain of Sortilin | x-ray diffraction | A, B | NAG, NA | 20 (best 0.72) |
| 5ZNN | Crystal structure of ligand-free form of the VPS10 ectodomain of sortilin | x-ray diffraction | A, B | NAG, NA | — |
| Q6PHU5 | AlphaFold monomer V2.0 prediction for sortilin (Q6PHU5) | predicted | A | — | 6 (best 0.83) |
Ligands
Experiment against prediction
- 5NMR chain A against the predicted model Q6PHU5: TM-score 0.99, RMSD 0.73 Å
- 5NMR chain A against the predicted model Q6PHU5: TM-score 0.99, RMSD 0.73 Å
- 5ZNN chain A against the predicted model Q6PHU5: TM-score 0.91, RMSD 3.16 Å
- 5ZNN chain A against the predicted model Q6PHU5: TM-score 0.91, RMSD 3.16 Å
- 5NNJ chain D against the predicted model Q6PHU5: TM-score 0.90, RMSD 3.12 Å
- 5NNJ chain C against the predicted model Q6PHU5: TM-score 0.90, RMSD 3.11 Å
- 5NNJ chain C against the predicted model Q6PHU5: TM-score 0.90, RMSD 3.11 Å
- 5NNJ chain B against the predicted model Q6PHU5: TM-score 0.90, RMSD 3.13 Å
- 5NNJ chain A against the predicted model Q6PHU5: TM-score 0.90, RMSD 3.14 Å
- 5NNJ chain A against the predicted model Q6PHU5: TM-score 0.90, RMSD 3.14 Å
Elsewhere
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