MolNFT v1 · #432904 · protein
AlphaFold monomer V2.0 prediction for sortilin (Q6PHU5)
Q6PHU5: “AlphaFold monomer V2.0 prediction for sortilin (Q6PHU5)”. 6 pockets (best druggability 0.83). MolNFT v1 #432904 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q6PHU5
- Type
- protein
- Length
- 825 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xF8cD1d8d93E9783063700De244A6e3cf6A195579
- Molecule
- Sortilin
- UniProt
- Q6PHU5
- Pockets
- 6 · best druggability 0.83
Structure
1 distinct chain · 9% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sortilin | protein | 825 | 9% helix, 33% strand | Q6PHU5 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1099 | 0.83 | 0.84 | 111 | empty |
| 2 | 492 | 0.65 | 0.77 | 53 | empty |
| 3 | 137 | 0.48 | 0.78 | 19 | empty |
| 4 | 161 | 0.41 | 0.74 | 21 | empty |
| 5 | 109 | 0.40 | 0.76 | 22 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 5NMT · Dimer structure of Sortilin ectodomain crystal form 1, 2.3A · an experimental structure of the same protein · chain A against B, TM-score 0.72
- 5NMT · Dimer structure of sortilin ectodomain crystal form 1, 2.3A · an experimental structure of the same protein · chain A against B, TM-score 0.72
- 5ZNN · Crystal structure of ligand-free form of the VPS10 ectodomain of sortilin · an experimental structure of the same protein · chain A against B, TM-score 0.72
- 5NNJ · Dimer structure of sortilin ectodomain crystal form 3, 4.0 ångström · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 5NNI · Dimer structure of Sortilin ectodomain crystal form 2, 3.2 Angstrom · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 5NNI · Dimer structure of sortilin ectodomain crystal form 2, 3.2 ångström · an experimental structure of the same protein · chain A against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PHU5
- Elsewhere: UniProt Q6PHU5 · AlphaFold DB Q6PHU5
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