UniProt Q6P179
Endoplasmic reticulum aminopeptidase 2 (Q6P179)
Endoplasmic reticulum aminopeptidase 2 (UniProt Q6P179), EC 3.4.11.-: 23 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 56 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q6P179
- Protein
- Endoplasmic reticulum aminopeptidase 2
- EC
- 3.4.11.-
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 56 · 3 records with a druggable one
Structures
24 records of Q6P179 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3SE6 | Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 | x-ray diffraction | A, B | — | — |
| 3SE6 | Crystal structure of the human endoplasmic reticulum aminopeptidase 2 | x-ray diffraction | A, B | — | — |
| 4E36 | Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 variant N392K | x-ray diffraction | A, B | — | — |
| 4E36 | Crystal structure of the human endoplasmic reticulum aminopeptidase 2 variant N392K | x-ray diffraction | A, B | — | — |
| 4JBS | Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 in complex with PHOSPHINIC… | x-ray diffraction | A, B | — | — |
| 4JBS | Crystal structure of the human endoplasmic reticulum aminopeptidase 2 in complex with phosphinic… | x-ray diffraction | A, B | — | — |
| 5AB0 | Crystal structure of aminopeptidase ERAP2 with ligand | x-ray diffraction | A, C | — | — |
| 5AB0 | Crystal structure of aminopeptidase ERAP2 with ligand | x-ray diffraction | A, C | — | — |
| 5AB2 | Crystal structure of aminopeptidase ERAP2 with ligand | x-ray diffraction | A, B | — | — |
| 5AB2 | Crystal structure of aminopeptidase ERAP2 with ligand | x-ray diffraction | A, B | — | — |
| 5CU5 | Crystal structure of ERAP2 without catalytic Zn(II) atom | x-ray diffraction | A, B | NAG, MAN | 16 (best 0.83) |
| 5CU5 | Crystal structure of ERAP2 without catalytic ZN(II) atom | x-ray diffraction | A, B | — | — |
| 5J6S | Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic… | x-ray diffraction | A, B | NAG, BMA, MAN, ZN, 6GA | — |
| 5J6S | Crystal structure of endoplasmic reticulum aminopeptidase 2 (ERAP2) in complex with a hydroxamic… | x-ray diffraction | A, B | — | — |
| 5K1V | Crystal structure of Endoplasmic Reticulum aminopeptidase 2 (ERAP2) in complex with a… | x-ray diffraction | A, B | NAG, MAN, ZN, 6PX | 20 (best 0.83) |
| 5K1V | Crystal structure of endoplasmic reticulum aminopeptidase 2 (ERAP2) in complex with a… | x-ray diffraction | A, B | NAG, MAN, ZN, 6PX | — |
| 6EA4 | ERAP2 bound to aryl sulfonamide uncompetitive inhibitor | x-ray diffraction | A, B | NAG, BMA, MAN, ZN, J2G | — |
| 7NSK | Endoplasmic reticulum aminopeptidase 2 complexed with a hydroxamic ligand | x-ray diffraction | A, B | NAG, BMA, MAN, ZN, P4G, UQE | — |
| 7NUP | Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand | x-ray diffraction | A, B, C, D | NAG, BMA, ZN, USK, BR | 20 (best 0.84) |
| 7NUP | Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand | x-ray diffraction | A, B, C, D | NAG, BMA, ZN, USK, BR | — |
| 7P7P | Crystal structure of ERAP2 aminopeptidase in complex with phosphinic… | x-ray diffraction | A, B | NAG, BMA, MAN, 62S, ZN | — |
| 7PFS | Crystal structure of ERAP2 aminopeptidase in complex with phosphinic pseudotripeptide… | x-ray diffraction | A, B | NAG, BMA, MAN, 7OO, ZN | — |
| 7SH0 | Crystal structure of endoplasmic reticulum aminopeptidase 2 (ERAP2) complex with a highly selective… | x-ray diffraction | A, B | ZN, GIY, NA | — |
| Q6P179 | AlphaFold monomer V2.0 prediction for endoplasmic reticulum aminopeptidase 2 (Q6P179) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 10 records
- ZN · Zinc ion · in 10 records
- MAN · alpha-D-mannopyranose · in 8 records
- BMA · beta-D-mannopyranose · in 7 records
- 6PX · methyl N-[4-amino-3-(L-arginylamino)benzene-1-carbonyl]-L-tyrosinate · in 2 records
- BR · Bromide ion · in 2 records
- USK · (3~{S})-4-(4-hydroxyphenyl)-~{N}-oxidanyl-3-[5-[[(5-phenylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]butanamide · in 2 records
- 62S · [(2~{S})-3-[[(2~{S})-1-azanyl-1-oxidanylidene-3-phenyl-propan-2-yl]amino]-2-[[3-(2-hydroxyphenyl)-1,2-oxazol-5-yl]methyl]-3-oxidanylidene-propyl]-[(1~{R})-1-azanyl-3-phenyl-propyl]phosphinic acid · in 1 record
- 6GA · (2S)-N~1~-benzyl-2-[(4-fluorophenyl)methyl]-N~3~-hydroxypropanediamide · in 1 record
- 7OO · [(2~{S})-3-[[(2~{S})-1-azanyl-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-2-[(3,5-diphenylphenyl)methyl]-3-oxidanylidene-propyl]-[(1~{R})-1-azanyl-3-phenyl-propyl]phosphinic acid · in 1 record
- GIY · (2S)-N-hydroxy-3-(4-methoxyphenyl)-2-[4-({[5-(pyridin-2-yl)thiophene-2-sulfonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propanamide · in 1 record
- J2G · 4-methoxy-3-{[2-(piperidin-1-yl)-4-(trifluoromethyl) phenyl]sulfamoyl}benzoic acid · in 1 record
- NA · Sodium ion · in 1 record
- P4G · 1-ethoxy-2-(2-ethoxyethoxy)ethane · in 1 record
- UQE · (2~{S})-3-(4-hydroxyphenyl)-~{N}-oxidanyl-2-[4-[[(5-pyridin-2-ylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]propanamide · in 1 record
Experiment against prediction
- 7NUP chain C against the predicted model Q6P179: TM-score 1.00, RMSD 0.53 Å
- 7NUP chain C against the predicted model Q6P179: TM-score 1.00, RMSD 0.53 Å
- 5K1V chain B against the predicted model Q6P179: TM-score 1.00, RMSD 0.61 Å
- 5K1V chain B against the predicted model Q6P179: TM-score 1.00, RMSD 0.61 Å
- 4JBS chain A against the predicted model Q6P179: TM-score 1.00, RMSD 0.56 Å
- 4JBS chain A against the predicted model Q6P179: TM-score 1.00, RMSD 0.56 Å
- 6EA4 chain B against the predicted model Q6P179: TM-score 1.00, RMSD 0.37 Å
- 5CU5 chain B against the predicted model Q6P179: TM-score 1.00, RMSD 0.61 Å
- 5CU5 chain B against the predicted model Q6P179: TM-score 1.00, RMSD 0.61 Å
- 5AB0 chain C against the predicted model Q6P179: TM-score 1.00, RMSD 0.62 Å
Elsewhere
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