UniProt Q6NXT2
Histone H3.3C (Q6NXT2)
Histone H3.3C (UniProt Q6NXT2): 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6NXT2
- Protein
- Histone H3.3C
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 14 · 5 records with a druggable one
Structures
11 records of Q6NXT2 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3KV4 | Structure of PHF8 in complex with histone H3 | x-ray diffraction | B | — | — |
| 3KV4 | Structure of PHF8 in complex with histone H3 | x-ray diffraction | B | — | — |
| 4Z5T | The nucleosome containing human H3.5 | x-ray diffraction | A, E | — | — |
| 4Z5T | The nucleosome containing human H3.5 | x-ray diffraction | A, E | — | — |
| 7W6L | The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide | x-ray diffraction | M | SAH | 1 (best 0.49) |
| 8Q1G | LSD1-CoREST bound to Acetylated K14 of Histone H3 | x-ray diffraction | C | FAD | 1 (best 0.85) |
| 8Q1J | LSD1 Y391K-CoREST bound to Acetylated K14 of Histone H3 | x-ray diffraction | C | FAD | 1 (best 0.83) |
| 8RBX | Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | electron microscopy | M, S | — | 3 (best 0.85) |
| 8SR6 | Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3… | x-ray diffraction | B | SAH | 3 (best 0.67) |
| 8T4F | Transporter associated with antigen processing (TAP) bound to the 9-mer peptide RRYQKSTEL | electron microscopy | C | — | 5 (best 0.68) |
| Q6NXT2 | AlphaFold monomer V2.0 prediction for histone H3.3C (Q6NXT2) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4Z5T chain E against the predicted model Q6NXT2: TM-score 0.99, RMSD 0.29 Å
- 4Z5T chain E against the predicted model Q6NXT2: TM-score 0.99, RMSD 0.29 Å
- 4Z5T chain A against the predicted model Q6NXT2: TM-score 0.99, RMSD 0.42 Å
- 4Z5T chain A against the predicted model Q6NXT2: TM-score 0.99, RMSD 0.42 Å
- 8RBX chain S against the predicted model Q6NXT2: TM-score 0.88, RMSD 1.34 Å
- 8RBX chain M against the predicted model Q6NXT2: TM-score 0.83, RMSD 1.74 Å
- 8T4F chain C against the predicted model Q6NXT2: TM-score 0.45, RMSD 1.08 Å
- 7W6L chain M against the predicted model Q6NXT2: TM-score 0.43, RMSD 1.11 Å
- 8Q1J chain C against the predicted model Q6NXT2: TM-score 0.26, RMSD 1.78 Å
- 3KV4 chain B against the predicted model Q6NXT2: TM-score 0.21, RMSD 1.79 Å
Elsewhere
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