UniProt Q6N5P6
Proline-tRNA ligase (Q6N5P6)
Proline-tRNA ligase (UniProt Q6N5P6), EC 6.1.1.15: 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 44 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6N5P6
- Protein
- Proline-tRNA ligase
- EC
- 6.1.1.15
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 44 · 5 records with a druggable one
Structures
9 records of Q6N5P6 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I4L | Rhodopseudomonas palustris prolyl-tRNA synthetase | x-ray diffraction | A, B, C | — | 11 (best 0.84) |
| 2I4L | Rhodopseudomonas palustris prolyl-tRNA synthetase | x-ray diffraction | A, B, C | — | — |
| 2I4M | Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with ProAMS | x-ray diffraction | A, B, C | P5A | 11 (best 0.85) |
| 2I4M | Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with proams | x-ray diffraction | A, B, C | — | — |
| 2I4N | Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with CysAMS | x-ray diffraction | A, B, C | 5CA | 9 (best 0.75) |
| 2I4N | Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with cysams | x-ray diffraction | A, B, C | — | — |
| 2I4O | Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with ATP | x-ray diffraction | A, B, C | MG, ATP | 12 (best 0.79) |
| 2I4O | Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with ATP | x-ray diffraction | A, B, C | — | — |
| Q6N5P6 | AlphaFold monomer V2.0 prediction for proline--tRNA ligase (Q6N5P6) | predicted | A | — | 1 (best 0.71) |
Ligands
Experiment against prediction
- 2I4M chain B against the predicted model Q6N5P6: TM-score 0.99, RMSD 0.54 Å
- 2I4M chain B against the predicted model Q6N5P6: TM-score 0.99, RMSD 0.54 Å
- 2I4N chain B against the predicted model Q6N5P6: TM-score 0.98, RMSD 0.61 Å
- 2I4N chain B against the predicted model Q6N5P6: TM-score 0.98, RMSD 0.61 Å
- 2I4N chain C against the predicted model Q6N5P6: TM-score 0.98, RMSD 0.69 Å
- 2I4N chain A against the predicted model Q6N5P6: TM-score 0.98, RMSD 0.70 Å
- 2I4N chain A against the predicted model Q6N5P6: TM-score 0.98, RMSD 0.70 Å
- 2I4L chain B against the predicted model Q6N5P6: TM-score 0.98, RMSD 1.13 Å
- 2I4L chain B against the predicted model Q6N5P6: TM-score 0.98, RMSD 1.13 Å
- 2I4M chain C against the predicted model Q6N5P6: TM-score 0.98, RMSD 1.17 Å
Elsewhere
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