UniProt Q62191
E3 ubiquitin-protein ligase TRIM21 (Q62191)
E3 ubiquitin-protein ligase TRIM21 (UniProt Q62191), EC 2.3.2.27: 93 experimental structures on GenesisL1, 88 ligands bound, 84 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q62191
- Protein
- E3 ubiquitin-protein ligase TRIM21
- EC
- 2.3.2.27
- Experimental structures
- 93
- Predicted models
- 0
- Ligands
- 88
- Pockets
- 84 · 0 records with a druggable one
Structures
93 records of Q62191 in the MolNFT archive: 93 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VOK | Murine TRIM21 | x-ray diffraction | A, B | — | — |
| 2VOK | Murine TRIM21 | x-ray diffraction | A, B | — | — |
| 3ZO0 | Mouse IgG2a in complex with mouse TRIM21 PRYSPRY | x-ray diffraction | B | — | — |
| 3ZO0 | Mouse IGG2A in complex with mouse TRIM21 pryspry | x-ray diffraction | B | — | — |
| 7HLA | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z111634612 | x-ray diffraction | B | A1BE6, SO4 | 1 (best 0.48) |
| 7HLB | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z45705015 | x-ray diffraction | B | S9S, SO4 | 1 (best 0.45) |
| 7HLC | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1079512010 | x-ray diffraction | B | UWS, SO4 | 1 (best 0.48) |
| 7HLD | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1401276297 | x-ray diffraction | B | U0S, SO4 | 1 (best 0.50) |
| 7HLE | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1696844792 | x-ray diffraction | B | UXG, SO4 | 1 (best 0.47) |
| 7HLG | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2365130785 | x-ray diffraction | B | SO4, A1BE8 | 1 (best 0.48) |
| 7HLH | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z453319206 | x-ray diffraction | B | SO4, LWD | 1 (best 0.49) |
| 7HLI | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2017861827 | x-ray diffraction | B | A1BE9, SO4 | 1 (best 0.47) |
| 7HLJ | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1980894300 | x-ray diffraction | B | TU6, SO4 | 1 (best 0.49) |
| 7HLK | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z285642082 | x-ray diffraction | B | SO4, UUP | 1 (best 0.46) |
| 7HLL | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1328968520 | x-ray diffraction | B | J4Q, SO4 | 1 (best 0.48) |
| 7HLM | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z29077827 | x-ray diffraction | B | GTJ, SO4 | 1 (best 0.47) |
| 7HLN | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z26823525 | x-ray diffraction | B | A1A4A, SO4 | 1 (best 0.46) |
| 7HLO | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z90122368 | x-ray diffraction | B | SO4, A1BFA | 1 (best 0.44) |
| 7HLP | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z29634868 | x-ray diffraction | B | SO4, A1BFB | — |
| 7HLQ | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z32327641 | x-ray diffraction | B | JMM, SO4 | 1 (best 0.47) |
| 7HLS | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z29177127 | x-ray diffraction | B | A1BFC, SO4 | 1 (best 0.47) |
| 7HLU | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z741055844 | x-ray diffraction | B | S0V, SO4 | 1 (best 0.46) |
| 7HLV | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z79432418 | x-ray diffraction | B | A1BFD, SO4 | 1 (best 0.47) |
| 7HLW | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z438096750 | x-ray diffraction | B | A1BFF, SO4 | 1 (best 0.45) |
| 7HLX | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z32367954 | x-ray diffraction | B | UXA, SO4 | 1 (best 0.48) |
| 7HLY | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z235449082 | x-ray diffraction | B | JFS, SO4 | 1 (best 0.48) |
| 7HLZ | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z256709358 | x-ray diffraction | B | BP4, SO4 | 1 (best 0.46) |
| 7HM1 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z793778804 | x-ray diffraction | B | VWV, SO4 | 1 (best 0.45) |
| 7HM2 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z32400357 | x-ray diffraction | B | NZJ, SO4 | 1 (best 0.46) |
| 7HM3 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1359419878 | x-ray diffraction | B | K6U, SO4 | 1 (best 0.47) |
| 7HM4 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1407673036 | x-ray diffraction | B | VW4, SO4 | 1 (best 0.47) |
| 7HM5 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z192955056 | x-ray diffraction | B | Q4L, SO4 | 1 (best 0.48) |
| 7HM6 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1172243962 | x-ray diffraction | B | A1BDJ, SO4 | 1 (best 0.46) |
| 7HM7 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1635496816 | x-ray diffraction | B | A1BFH, SO4 | 1 (best 0.47) |
| 7HM8 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z285782452 | x-ray diffraction | B | UVA, SO4 | 1 (best 0.48) |
| 7HM9 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1222331430 | x-ray diffraction | B | A1BFI, SO4 | 1 (best 0.47) |
| 7HMA | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z291279160 | x-ray diffraction | B | LV4, SO4 | 1 (best 0.47) |
| 7HMC | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1954800564 | x-ray diffraction | B | NZ1, SO4 | 1 (best 0.47) |
| 7HMD | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z425387594 | x-ray diffraction | B | H04, SO4 | 1 (best 0.47) |
| 7HMF | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1367324110 | x-ray diffraction | B | RZJ, SO4 | 1 (best 0.44) |
| 7HMG | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z274575916 | x-ray diffraction | B | WKS, SO4 | 1 (best 0.48) |
| 7HMI | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1742054999 | x-ray diffraction | B | A1BFK, SO4 | 1 (best 0.46) |
| 7HMJ | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1578665941 | x-ray diffraction | B | K1P, SO4 | 1 (best 0.47) |
| 7HMK | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z271004858 | x-ray diffraction | B | SFY, SO4 | — |
| 7HML | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1354416068 | x-ray diffraction | B | X1J, SO4 | 1 (best 0.47) |
| 7HMM | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z165170770 | x-ray diffraction | B | W0Y, SO4 | 1 (best 0.46) |
| 7HMN | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z57478994 | x-ray diffraction | B | UVS, SO4 | 1 (best 0.48) |
| 7HMO | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z198194394 | x-ray diffraction | B | O1M, SO4 | 1 (best 0.46) |
| 7HMP | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1530301542 | x-ray diffraction | B | ZQA, SO4 | 1 (best 0.46) |
| 7HMQ | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1267773633 | x-ray diffraction | B | A1A36, SO4 | 1 (best 0.46) |
| 7HMR | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1267882044 | x-ray diffraction | B | A1BFL, SO4 | 1 (best 0.48) |
| 7HMS | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z126932614 | x-ray diffraction | B | T6J, SO4 | 1 (best 0.44) |
| 7HMT | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2004563941 | x-ray diffraction | B | A1BFM, SO4 | 1 (best 0.46) |
| 7HMV | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z56978034 | x-ray diffraction | B | U2R, SO4 | — |
| 7HMW | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1492796719 | x-ray diffraction | B | S7G, SO4 | 1 (best 0.45) |
| 7HMX | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z763030030 | x-ray diffraction | B | WJA, SO4 | 1 (best 0.48) |
| 7HMY | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z111782404 | x-ray diffraction | B | ZTQ, SO4 | 1 (best 0.47) |
| 7HMZ | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z85893853 | x-ray diffraction | B | A1BFN, SO4 | 1 (best 0.46) |
| 7HN2 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1002247062 | x-ray diffraction | B | A1BFP, SO4 | 1 (best 0.47) |
| 7HN3 | PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2301438417 | x-ray diffraction | B | A1BFQ, SO4 | 1 (best 0.47) |
33 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 88 records
- A1A36 · 1-(2-ethyl-1,3-thiazol-5-yl)-N-methylmethanamine · in 1 record
- A1A3W · (1R)-N-methyl-1-(pyridin-4-yl)propan-1-amine · in 1 record
- A1A4A · (2S)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)oxolane-2-carboxamide · in 1 record
- A1AP3 · 1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]pyridin-2(1H)-one · in 1 record
- A1BDJ · 5-fluoro-N-(oxan-4-yl)pyridin-2-amine · in 1 record
- A1BE6 · (8R)-2-methyl-5-(propan-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one · in 1 record
- A1BE8 · (1r,3r)-3-[(3-fluoropyridin-2-yl)amino]-1-methylcyclobutan-1-ol · in 1 record
- A1BE9 · 1-[(1S,4S)-1,2,3,4-tetrahydro-1,4-(epiminomethano)naphthalen-10-yl]ethan-1-one · in 1 record
- A1BF0 · N-[(3S)-1-propanoylpiperidin-3-yl]methanesulfonamide · in 1 record
- A1BF1 · 4-benzylpiperazine-2,6-dione · in 1 record
- A1BFA · 4-acetylpiperazine-1-carboxamide · in 1 record
- A1BFB · 2-oxo-4-propyl-2H-1-benzopyran-7-yl acetate · in 1 record
- A1BFC · 3-(2-methylpropanamido)benzamide · in 1 record
- A1BFD · 2-(2-oxopyrrolidin-1-yl)-N-(1,3-thiazol-2-yl)acetamide · in 1 record
- A1BFF · N-{[(3S)-1-acetylpiperidin-3-yl]methyl}methanesulfonamide · in 1 record
- A1BFH · N-(6-methyl-2H-1,3-benzodioxol-5-yl)acetamide · in 1 record
- A1BFI · N,N-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxamide · in 1 record
- A1BFK · N,N-dimethyl-5-(piperidin-4-yl)-1,2,4-oxadiazol-3-amine · in 1 record
- A1BFL · N-{[(2R)-oxolan-2-yl]methyl}pyridin-4-amine · in 1 record
- A1BFM · (1R)-1-(1-cyclopentyl-1H-pyrazol-4-yl)ethan-1-ol · in 1 record
- A1BFN · (3S)-1-[(4-fluorophenyl)acetyl]piperidine-3-carboxylic acid · in 1 record
- A1BFP · N-{[(2R)-4-methylmorpholin-2-yl]methyl}-1,3-thiazol-2-amine · in 1 record
- A1BFQ · 1,3-dimethyl-1H-pyrazolo[3,4-d]pyridazin-7-ol · in 1 record
- A1BFR · (5S)-N,N-dimethyl-2,9-dioxa-6-azaspiro[4.5]decane-6-carboxamide · in 1 record
- A1BFT · (3S,4S)-3-methoxy-4-methyl-1-[(1,3-thiazol-5-yl)methyl]piperidine · in 1 record
- A1BFU · 1-(3-methoxyazetidine-1-sulfonyl)pyrrolidine · in 1 record
- A1BFV · (5-fluoro-3,6-dihydropyridin-1(2H)-yl)(morpholin-4-yl)methanone · in 1 record
- A1BFW · 1-methyl-N-{[(2S)-oxolan-2-yl]methyl}-1H-pyrazole-3-carboxamide · in 1 record
- A1BFY · N-[(9S)-6-oxaspiro[4.5]decan-9-yl]methanesulfonamide · in 1 record
Elsewhere
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