UniProt Q5W0Q7
SUMO-specific isopeptidase USPL1 (Q5W0Q7)
SUMO-specific isopeptidase USPL1 (UniProt Q5W0Q7), EC 3.4.22.-: 4 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q5W0Q7
- Protein
- SUMO-specific isopeptidase USPL1
- EC
- 3.4.22.-
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 26 · 4 records with a druggable one
Structures
5 records of Q5W0Q7 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7P99 | Structure of human USPL1 in complex with SUMO2 | x-ray diffraction | A | ZN | 5 (best 0.57) |
| 7P99 | Structure of human USPL1 in complex with SUMO2 | x-ray diffraction | A | ZN | — |
| 7ZJU | Structure of human USPL1 in covalent complex with SUMO3-2Br probe | x-ray diffraction | A, C | ZN, OXU, CL, CA | 9 (best 0.77) |
| 7ZJV | Structure of human USPL1 in covalent complex with DeltaN-SUMO2/3-PA probe | x-ray diffraction | A | ZN, AYE, CL | 5 (best 0.58) |
| Q5W0Q7 | AlphaFold monomer V2.0 prediction for sumo-specific isopeptidase USPL1 (Q5W0Q7) | predicted | A | — | 7 (best 0.61) |
Ligands
Experiment against prediction
- 7ZJU chain A against the predicted model Q5W0Q7: TM-score 0.99, RMSD 0.56 Å
- 7ZJU chain C against the predicted model Q5W0Q7: TM-score 0.99, RMSD 0.58 Å
- 7ZJV chain A against the predicted model Q5W0Q7: TM-score 0.98, RMSD 0.82 Å
- 7P99 chain A against the predicted model Q5W0Q7: TM-score 0.98, RMSD 0.98 Å
- 7P99 chain A against the predicted model Q5W0Q7: TM-score 0.98, RMSD 0.98 Å
Elsewhere
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