MolNFT v1 · #184962 · protein

Structure of human USPL1 in complex with SUMO2

7P99 · Sumo-specific isopeptidase USPL1: “Structure of human USPL1 in complex with SUMO2”. X-ray diffraction, 1 ligand (ZN), 5 pockets (best druggability 0.57). MolNFT v1 #184962 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7P99
Type: protein
Length: 345 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sumo-specific isopeptidase USPL1; Small ubiquitin-related modifier
EC: 3.4.22.-
UniProt: Q5W0Q7, A0A6J0CIQ7
Ligands: ZN
Pockets: 5 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sumo-specific isopeptidase USPL1 (EC 3.4.22.-)	protein	266	33% helix, 31% strand	Q5W0Q7
C	Small ubiquitin-related modifier	protein	79	23% helix, 34% strand	A0A6J0CIQ7

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	292	0.57	0.77	33	empty
2	137	0.52	0.80	24	empty
3	106	0.47	0.79	17	empty
4	142	0.41	0.74	28	empty
5	54	0.29	0.75	12	empty

Interfaces

1 interface between chains.

A–C · 1237 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

7P99 · Structure of human USPL1 in complex with SUMO2 · the same entry in another collection · chain A against A, TM-score 1.00
Q5W0Q7 · AlphaFold monomer V2.0 prediction for sumo-specific isopeptidase USPL1 (Q5W0Q7) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5W0Q7
Every structure of UniProt A0A6J0CIQ7
Elsewhere: RCSB PDB 7P99 · PDBe 7P99 · UniProt Q5W0Q7 · UniProt A0A6J0CIQ7

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