UniProt Q5NDF2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (Q5NDF2)
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (UniProt Q5NDF2), EC 2.4.1.312: 6 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 53 pockets. Binding sites, druggability and…
- UniProt
- Q5NDF2
- Protein
- Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
- EC
- 2.4.1.312
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 53 · 4 records with a druggable one
Structures
7 records of Q5NDF2 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7E9J | Crystal Structure of POMGNT2 in complex with UDP | x-ray diffraction | A, B | NAG, UDP | 15 (best 0.68) |
| 7E9J | Crystal structure of POMGNT2 in complex with udp | x-ray diffraction | A, B | NAG, UDP | — |
| 7E9K | Crystal Structure of POMGNT2 in complex with UDP and mono-mannosyl peptide (379Man long peptide) | x-ray diffraction | A, B, D, E | NAG, UDP, MAN | 20 (best 0.77) |
| 7E9K | Crystal structure of POMGNT2 in complex with udp and mono-mannosyl peptide (379MAN long peptide) | x-ray diffraction | A, B, D, E | NH2, NAG, UDP, MAN | — |
| 7E9L | Crystal Structure of POMGNT2 in complex with UDP and mono-mannosyl peptide (379Man short peptide) | x-ray diffraction | A, B | NAG, UDP, MAN | 14 (best 0.74) |
| 7E9L | Crystal structure of POMGNT2 in complex with udp and mono-mannosyl peptide (379MAN short peptide) | x-ray diffraction | A, B | ACE, NH2, NAG, UDP, MAN | — |
| Q5NDF2 | AlphaFold monomer V2.0 prediction for protein O-linked-mannose… | predicted | A | — | 4 (best 0.70) |
Ligands
Experiment against prediction
- 7E9L chain B against the predicted model Q5NDF2: TM-score 0.94, RMSD 2.09 Å
- 7E9L chain B against the predicted model Q5NDF2: TM-score 0.94, RMSD 2.09 Å
- 7E9K chain B against the predicted model Q5NDF2: TM-score 0.93, RMSD 2.29 Å
- 7E9K chain B against the predicted model Q5NDF2: TM-score 0.93, RMSD 2.29 Å
- 7E9L chain A against the predicted model Q5NDF2: TM-score 0.93, RMSD 2.24 Å
- 7E9L chain A against the predicted model Q5NDF2: TM-score 0.93, RMSD 2.24 Å
- 7E9K chain E against the predicted model Q5NDF2: TM-score 0.92, RMSD 2.52 Å
- 7E9K chain E against the predicted model Q5NDF2: TM-score 0.92, RMSD 2.52 Å
- 7E9J chain B against the predicted model Q5NDF2: TM-score 0.92, RMSD 2.52 Å
- 7E9K chain D against the predicted model Q5NDF2: TM-score 0.92, RMSD 2.63 Å
Elsewhere
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