UniProt Q5MCK9
Serine hydroxymethyltransferase (Q5MCK9)
Serine hydroxymethyltransferase (UniProt Q5MCK9), EC 2.1.2.1: 10 experimental structures on GenesisL1, 8 ligands bound, 75 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q5MCK9
- Protein
- Serine hydroxymethyltransferase
- EC
- 2.1.2.1
- Experimental structures
- 10
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 75 · 5 records with a druggable one
Structures
10 records of Q5MCK9 in the MolNFT archive: 10 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6TGH | SHMT from Streptococcus thermophilus Tyr55Thr variant in complex with D-Serine both as external… | x-ray diffraction | A, C, B, D | NA, EVM, DSN, PLP | 18 (best 0.83) |
| 6TGH | Shmt from streptococcus thermophilus TYR55THR variant in complex with D-serine both as external… | x-ray diffraction | A, C, B, D | NA, PLP | — |
| 6TI1 | SHMT from Streptococcus thermophilus Tyr55Ser variant in complex with PLP/L-Threonine/Lys230 gem… | x-ray diffraction | A, C | 2BO, NA | 9 (best 0.75) |
| 6TI1 | Shmt from streptococcus thermophilus TYR55SER variant in complex with PLP/L-THREONINE/LYS230 gem… | x-ray diffraction | A, C | NA | — |
| 6TI3 | Apo-SHMT from Streptococcus thermophilus Tyr55Ser variant in complex with D-Threonine | x-ray diffraction | A, C, B, D | DTH, NA | 19 (best 0.82) |
| 6TI3 | Apo-shmt from streptococcus thermophilus TYR55SER variant in complex with D-threonine | x-ray diffraction | A, C, B, D | NA | — |
| 6TI4 | SHMT from Streptococcus thermophilus Tyr55Ser variant in complex with PLP/D-Serine/Lys230 gem… | x-ray diffraction | A, C | O3Z, MG | 9 (best 0.74) |
| 6TI4 | Shmt from streptococcus thermophilus TYR55SER variant in complex with PLP/D-SERINE/LYS230 gem… | x-ray diffraction | A, C | MG | — |
| 6YRW | SHMT from Streptococcus thermophilus Tyr55Ser variant as internal aldimine and as non-covalent… | x-ray diffraction | A, C, B, D | PLP, DSN | 20 (best 0.80) |
| 6YRW | Shmt from streptococcus thermophilus TYR55SER variant as internal aldimine and as non-covalent… | x-ray diffraction | A, C, B, D | PLP | — |
Ligands
- NA · Sodium ion · in 6 records
- PLP · Pyridoxal-5'-phosphate · in 4 records
- DSN · D-serine · in 2 records
- MG · Magnesium ion · in 2 records
- 2BO · N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-threonine · in 1 record
- DTH · D-threonine · in 1 record
- EVM · L-Serine, N-[[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methylene] · in 1 record
- O3Z · (2~{R})-2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]-3-oxidanyl-propanoic acid · in 1 record
Elsewhere
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