UniProt Q5JTZ9
Alanine--tRNA ligase, mitochondrial (Q5JTZ9)
Alanine--tRNA ligase, mitochondrial (UniProt Q5JTZ9), EC 6.1.1.7: 6 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q5JTZ9
- Protein
- Alanine--tRNA ligase, mitochondrial
- EC
- 6.1.1.7
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 23 · 4 records with a druggable one
Structures
7 records of Q5JTZ9 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6NLQ | Human Mitochondrial Alanyl-tRNA Synthetase C-terminal domain | x-ray diffraction | A, B, C, D | CA | 2 (best 0.77) |
| 6NLQ | Human mitochondrial alanyl-tRNA synthetase C-terminal domain | x-ray diffraction | A, B, C, D | CA | — |
| 6NLY | Fragment of human mitochondrial Alanyl-tRNA Synthetase C-Ala domain | x-ray diffraction | B, A, C, D | — | 4 (best 0.70) |
| 6NLY | Fragment of human mitochondrial alanyl-tRNA synthetase C-ala domain | x-ray diffraction | B, A, C, D | — | — |
| 6NOW | Human Mitochondrial Alanyl-tRNA Synthetase C-Ala domain | x-ray diffraction | A, B | — | 10 (best 0.61) |
| 6NOW | Human mitochondrial alanyl-tRNA synthetase C-ala domain | x-ray diffraction | A, B | — | — |
| Q5JTZ9 | AlphaFold monomer V2.0 prediction for alanine--tRNA ligase, mitochondrial (Q5JTZ9) | predicted | A | — | 7 (best 0.81) |
Ligands
- CA · Calcium ion · in 2 records
Experiment against prediction
- 6NLQ chain B against the predicted model Q5JTZ9: TM-score 0.98, RMSD 0.59 Å
- 6NLQ chain B against the predicted model Q5JTZ9: TM-score 0.98, RMSD 0.59 Å
- 6NLQ chain A against the predicted model Q5JTZ9: TM-score 0.97, RMSD 0.86 Å
- 6NLQ chain A against the predicted model Q5JTZ9: TM-score 0.97, RMSD 0.86 Å
- 6NOW chain A against the predicted model Q5JTZ9: TM-score 0.94, RMSD 1.34 Å
- 6NOW chain A against the predicted model Q5JTZ9: TM-score 0.94, RMSD 1.34 Å
- 6NLY chain A against the predicted model Q5JTZ9: TM-score 0.93, RMSD 1.26 Å
- 6NLY chain A against the predicted model Q5JTZ9: TM-score 0.93, RMSD 1.26 Å
- 6NOW chain B against the predicted model Q5JTZ9: TM-score 0.93, RMSD 1.42 Å
- 6NOW chain B against the predicted model Q5JTZ9: TM-score 0.93, RMSD 1.42 Å
Elsewhere
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