MolNFT v1 · #158269 · protein
Human mitochondrial alanyl-tRNA synthetase C-ala domain
6NOW · Alanine--tRNA ligase, mitochondrial: “Human mitochondrial alanyl-tRNA synthetase C-ala domain”. X-ray diffraction, 10 pockets (best druggability 0.61). MolNFT v1 #158269 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NOW
- Type
- protein
- Length
- 397 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alanine--tRNA ligase, mitochondrial
- EC
- 6.1.1.7
- UniProt
- Q5JTZ9
- Pockets
- 10 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 61% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) | protein | 201 | 62% helix, 15% strand | Q5JTZ9 |
| B | Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) | protein | 196 | 60% helix, 15% strand | Q5JTZ9 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.61 | 0.87 | 26 | empty |
| 2 | 68 | 0.55 | 0.87 | 18 | empty |
| 3 | 69 | 0.53 | 0.86 | 17 | empty |
| 4 | 164 | 0.51 | 0.78 | 21 | empty |
| 5 | 87 | 0.49 | 0.82 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1265 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6NOW · Human Mitochondrial Alanyl-tRNA Synthetase C-Ala domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q5JTZ9 · AlphaFold monomer V2.0 prediction for alanine--tRNA ligase, mitochondrial (Q5JTZ9) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5JTZ9
- Elsewhere: RCSB PDB 6NOW · PDBe 6NOW · UniProt Q5JTZ9
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