UniProt Q58605
S-adenosylmethionine synthase (Q58605)
S-adenosylmethionine synthase (UniProt Q58605), EC 2.5.1.6: 5 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q58605
- Protein
- S-adenosylmethionine synthase
- EC
- 2.5.1.6
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 10 · 1 record with a druggable one
Structures
6 records of Q58605 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7P82 | Crystal structure of apo form L147A/I351A variant of S- adenosylmethionine synthetase from… | x-ray diffraction | A, C | — | — |
| 7P83 | Crystal structure of apo form of S-adenosylmethionine synthetase from methanocaldococcus jannaschii | x-ray diffraction | A, C | — | — |
| 7P84 | Crystal structure of L147A/I351A variant of S-adenosylmethionine synthetase from Methanocaldococcus… | x-ray diffraction | A, C | 3PO, MG, EU9 | 10 (best 0.82) |
| 7P84 | Crystal structure of L147A/I351A variant of S-adenosylmethionine synthetase from methanocaldococcus… | x-ray diffraction | A, C | 3PO, MG, EU9 | — |
| 7P8M | Crystal structure of L147A/I351A variant of S-adenosylmethionine synthetase from methanocaldococcus… | x-ray diffraction | A, C | 3PO, MG, 6IH | — |
| Q58605 | AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase (Q58605) | predicted | A | — | — |
Ligands
- 3PO · Triphosphate · in 3 records
- MG · Magnesium ion · in 3 records
- EU9 · [(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl) oxolan-2-yl]methyl-[(3R)-3-azanyl-4-oxidanyl-4-oxidanylidene-butyl]-[(2-nitrophenyl)methyl]sulfanium · in 2 records
- 6IH · 4,5-dimethoxy-2-nitro benzyme S-adenosyl-methionine · in 1 record
Experiment against prediction
- 7P83 chain C against the predicted model Q58605: TM-score 0.98, RMSD 0.96 Å
- 7P84 chain C against the predicted model Q58605: TM-score 0.98, RMSD 0.98 Å
- 7P84 chain C against the predicted model Q58605: TM-score 0.98, RMSD 0.98 Å
- 7P8M chain C against the predicted model Q58605: TM-score 0.98, RMSD 0.98 Å
- 7P82 chain C against the predicted model Q58605: TM-score 0.98, RMSD 0.99 Å
- 7P82 chain A against the predicted model Q58605: TM-score 0.97, RMSD 1.55 Å
- 7P8M chain A against the predicted model Q58605: TM-score 0.97, RMSD 1.52 Å
- 7P84 chain A against the predicted model Q58605: TM-score 0.97, RMSD 1.55 Å
- 7P84 chain A against the predicted model Q58605: TM-score 0.97, RMSD 1.55 Å
- 7P83 chain A against the predicted model Q58605: TM-score 0.97, RMSD 1.55 Å
Elsewhere
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