MolNFT v1 · #184930 · protein
Crystal structure of apo form of S-adenosylmethionine synthetase from methanocaldococcus jannaschii
7P83 · S-adenosylmethionine synthase: “Crystal structure of apo form of S-adenosylmethionine synthetase from methanocaldococcus jannaschii”. X-ray diffraction, 8 pockets (best druggability 0.84). MolNFT v1 #184930 on GenesisL1: 3D…
- PDB
- 7P83
- Type
- protein
- Length
- 810 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S-adenosylmethionine synthase
- EC
- 2.5.1.6
- UniProt
- Q58605
- Pockets
- 8 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | S-adenosylmethionine synthase (EC 2.5.1.6) | protein | 404 | 35% helix, 28% strand | Q58605 |
| C | S-adenosylmethionine synthase (EC 2.5.1.6) | protein | 406 | 34% helix, 29% strand | Q58605 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1156 | 0.84 | 0.84 | 100 | empty |
| 2 | 496 | 0.80 | 0.87 | 66 | empty |
| 3 | 367 | 0.58 | 0.76 | 40 | empty |
| 4 | 337 | 0.56 | 0.75 | 45 | empty |
| 5 | 158 | 0.52 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–C · 2591 Ų buried · 38 hydrogen bonds · protein-protein
Compared structures
- 7P83 · Crystal structure of Apo form of S-adenosylmethionine synthetase from Methanocaldococcus… · the same entry in another collection · chain A against A, TM-score 1.00
- Q58605 · AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase (Q58605) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q58605
- Elsewhere: RCSB PDB 7P83 · PDBe 7P83 · UniProt Q58605
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