UniProt Q52428
Aspartyl-tRNA synthetase (Q52428)
Aspartyl-tRNA synthetase (UniProt Q52428), EC 6.1.1.12: 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 62 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q52428
- Protein
- Aspartyl-tRNA synthetase
- EC
- 6.1.1.12
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 62 · 9 records with a druggable one
Structures
9 records of Q52428 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B8A | Aspartyl-tRNA synthetase | x-ray diffraction | A, B | MN, ATP | 8 (best 0.76) |
| 1B8A | Aspartyl-tRNA synthetase | x-ray diffraction | A, B | MN, ATP | 8 (best 0.76) |
| 3NEL | Aspartyl-tRNA synthetase complexed with aspartic acid | x-ray diffraction | A, B | ASP | 8 (best 0.74) |
| 3NEL | Aspartyl-tRNA synthetase complexed with aspartic acid | x-ray diffraction | A, B | ASP | 8 (best 0.74) |
| 3NEM | Aspartyl-tRNA synthetase complexed with aspartyl adenylate | x-ray diffraction | A, B | AMO, ATP, MG | 7 (best 0.76) |
| 3NEM | Aspartyl-tRNA synthetase complexed with aspartyl adenylate | x-ray diffraction | A, B | AMO, ATP, MG | 7 (best 0.76) |
| 3NEN | Unliganded aspartyl-tRNA synthetase from thermococcus kodakarensis | x-ray diffraction | A, B | — | 7 (best 0.73) |
| 3NEN | Unliganded aspartyl-tRNA synthetase from thermococcus kodakarensis | x-ray diffraction | A, B | — | 7 (best 0.73) |
| Q52428 | AlphaFold monomer V2.0 prediction for aspartate--TRNA(ASP) ligase (Q52428) | predicted | A | — | 2 (best 0.71) |
Ligands
Experiment against prediction
- 3NEM chain A against the predicted model Q52428: TM-score 1.00, RMSD 0.36 Å
- 3NEM chain A against the predicted model Q52428: TM-score 1.00, RMSD 0.36 Å
- 1B8A chain A against the predicted model Q52428: TM-score 1.00, RMSD 0.44 Å
- 1B8A chain A against the predicted model Q52428: TM-score 1.00, RMSD 0.44 Å
- 3NEL chain A against the predicted model Q52428: TM-score 1.00, RMSD 0.45 Å
- 3NEL chain A against the predicted model Q52428: TM-score 1.00, RMSD 0.45 Å
- 3NEN chain A against the predicted model Q52428: TM-score 1.00, RMSD 0.46 Å
- 3NEN chain A against the predicted model Q52428: TM-score 1.00, RMSD 0.46 Å
- 3NEM chain B against the predicted model Q52428: TM-score 0.99, RMSD 0.68 Å
- 3NEM chain B against the predicted model Q52428: TM-score 0.99, RMSD 0.68 Å
Elsewhere
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