UniProt Q4G0J3
La-related protein 7 (Q4G0J3)
La-related protein 7 (UniProt Q4G0J3): 10 experimental structures and 1 predicted model on GenesisL1, 57 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q4G0J3
- Protein
- La-related protein 7
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 57 · 7 records with a druggable one
Structures
11 records of Q4G0J3 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WKR | LaRP7 wrapping up the 3' hairpin of 7SK non-coding RNA (302-332) | x-ray diffraction | A, B | — | 5 (best 0.48) |
| 4WKR | LARP7 wrapping up the 3' hairpin of 7SK non-coding RNA (302-332) | x-ray diffraction | A, B | — | 5 (best 0.48) |
| 5KNW | Solution NMR structure of human LARP7 xRRM2 | solution nmr | A | — | — |
| 5KNW | Solution NMR structure of human LARP7 XRRM2 | solution nmr | A | — | — |
| 6D12 | Crystal structure of C-terminal xRRM domain of human Larp7 bound to 7SK stem-loop 4 RNA | x-ray diffraction | A, B | — | 1 (best 0.54) |
| 6D12 | Crystal structure of C-terminal xrrm domain of human LARP7 bound to 7SK stem-loop 4 RNA | x-ray diffraction | A, B | — | 1 (best 0.54) |
| 7SLP | Cryo-EM structure of 7SK core RNP with linear RNA | electron microscopy | B | — | 10 (best 0.72) |
| 7SLP | Cryo-EM structure of 7SK core rnp with linear RNA | electron microscopy | B | — | 10 (best 0.72) |
| 7SLQ | Cryo-EM structure of 7SK core RNP with circular RNA | electron microscopy | B | — | 10 (best 0.69) |
| 7SLQ | Cryo-EM structure of 7SK core rnp with circular RNA | electron microscopy | B | — | 10 (best 0.69) |
| Q4G0J3 | AlphaFold monomer V2.0 prediction for la-related protein 7 (Q4G0J3) | predicted | A | — | 5 (best 0.57) |
Experiment against prediction
- 4WKR chain A against the predicted model Q4G0J3: TM-score 0.96, RMSD 1.09 Å
- 4WKR chain A against the predicted model Q4G0J3: TM-score 0.96, RMSD 1.09 Å
- 6D12 chain A against the predicted model Q4G0J3: TM-score 0.95, RMSD 0.94 Å
- 6D12 chain A against the predicted model Q4G0J3: TM-score 0.95, RMSD 0.94 Å
- 6D12 chain B against the predicted model Q4G0J3: TM-score 0.95, RMSD 0.94 Å
- 6D12 chain B against the predicted model Q4G0J3: TM-score 0.95, RMSD 0.94 Å
- 7SLQ chain B against the predicted model Q4G0J3: TM-score 0.75, RMSD 3.65 Å
- 7SLQ chain B against the predicted model Q4G0J3: TM-score 0.75, RMSD 3.65 Å
- 7SLP chain B against the predicted model Q4G0J3: TM-score 0.74, RMSD 3.99 Å
- 7SLP chain B against the predicted model Q4G0J3: TM-score 0.74, RMSD 3.99 Å
Elsewhere
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