MolNFT v1 · #108869 · protein + RNA
LARP7 wrapping up the 3' hairpin of 7SK non-coding RNA (302-332)
4WKR · La-related protein 7: “LARP7 wrapping up the 3' hairpin of 7SK non-coding RNA (302-332)”. X-ray diffraction, 5 pockets (best druggability 0.48). MolNFT v1 #108869 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4WKR
- Type
- protein + RNA
- Length
- 330 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- La-related protein 7; 7SK GGHP4 (300-332)
- UniProt
- Q4G0J3
- Pockets
- 5 · best druggability 0.48
Structure
x-ray diffraction · 3 distinct chains · 42% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | La-related protein 7 | protein | 161 | 42% helix, 14% strand | Q4G0J3 |
| C | 7SK GGHP4 (300-332) | rna | 3 | — | — |
| D | 7SK GGHP4 (300-332) | rna | 5 | — | — |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 222 | 0.48 | 0.74 | 25 | empty |
| 2 | 205 | 0.46 | 0.74 | 31 | empty |
| 3 | 106 | 0.39 | 0.75 | 15 | empty |
| 4 | 134 | 0.38 | 0.73 | 23 | empty |
| 5 | 50 | 0.31 | 0.76 | 17 | empty |
Interfaces
3 interfaces between chains.
- B–D · 545 Ų buried · 13 hydrogen bonds · protein-nucleic
- A–C · 428 Ų buried · 17 hydrogen bonds · protein-nucleic
- A–B · 68 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4G0J3
- Elsewhere: RCSB PDB 4WKR · PDBe 4WKR · UniProt Q4G0J3
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