MolNFT v1 · #145884 · protein + RNA
Crystal structure of C-terminal xrrm domain of human LARP7 bound to 7SK stem-loop 4 RNA
6D12 · La-related protein 7: “Crystal structure of C-terminal xrrm domain of human LARP7 bound to 7SK stem-loop 4 RNA”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #145884 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6D12
- Type
- protein + RNA
- Length
- 241 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- La-related protein 7; Human 7SK RNA stem-loop 4
- UniProt
- Q4G0J3
- Pockets
- 1 · best druggability 0.54
Structure
x-ray diffraction · 3 distinct chains · 43% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | La-related protein 7 | protein | 100 | 43% helix, 22% strand | Q4G0J3 |
| B | La-related protein 7 | protein | 103 | 43% helix, 21% strand | Q4G0J3 |
| C | Human 7SK RNA stem-loop 4 | rna | 38 | — | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 427 | 0.54 | 0.73 | 27 | empty |
Interfaces
2 interfaces between chains.
- B–C · 723 Ų buried · 29 hydrogen bonds · protein-nucleic
- A–C · 601 Ų buried · 25 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 6D12 · Crystal structure of C-terminal xRRM domain of human Larp7 bound to 7SK stem-loop 4 RNA · the same entry in another collection · chain A against A, TM-score 1.00
- Q4G0J3 · AlphaFold monomer V2.0 prediction for la-related protein 7 (Q4G0J3) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4G0J3
- Elsewhere: RCSB PDB 6D12 · PDBe 6D12 · UniProt Q4G0J3
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