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UniProt Q4DLS1

Bifunctional dihydrofolate reductase-thymidylate synthase (Q4DLS1)

Bifunctional dihydrofolate reductase-thymidylate synthase (UniProt Q4DLS1): 2 experimental structures on GenesisL1, 3 ligands bound, 20 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
Q4DLS1
Protein
Bifunctional dihydrofolate reductase-thymidylate synthase
Experimental structures
2
Predicted models
0
Ligands
3
Pockets
20 · 1 record with a druggable one

Structures

2 records of Q4DLS1 in the MolNFT archive: 2 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
5T7OCrystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with…x-ray diffractionA, B, C, DNAP, THG, UMP20 (best 0.82)
5T7OCrystal structure of trypanosoma cruzi dihydrofolate reductase- thymidylate synthase in complex…x-ray diffractionA, B, C, DNAP, UMP—

Ligands

  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 2 records
  • UMP · 2'-deoxyuridine 5'-monophosphate · in 2 records
  • THG · (6S)-5,6,7,8-tetrahydrofolate · in 1 record

Elsewhere

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