MolNFT v1 · #134556 · protein
Crystal structure of trypanosoma cruzi dihydrofolate reductase- thymidylate synthase in complex with (6S)-5,6,7,8-tetrahydrofolate
5T7O: “Crystal structure of trypanosoma cruzi dihydrofolate reductase- thymidylate synthase in complex with…”. X-ray diffraction, 2 ligands (NAP, UMP). MolNFT v1 #134556 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5T7O
- Type
- protein
- Length
- 1,969 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q4DLS1
- Ligands
- NAP, UMP
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 495 | — | Q4DLS1 |
| B | — | protein | 496 | — | Q4DLS1 |
| C | — | protein | 488 | — | Q4DLS1 |
| D | — | protein | 490 | — | Q4DLS1 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 4 copies · chains A, B, C, D
- UMP · 2'-deoxyuridine 5'-monophosphate · ligand · 4 copies · chains A, B, C, D
- EDO · 1,2-ethanediol · additive · 47 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5T7O · Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4DLS1
- Elsewhere: RCSB PDB 5T7O · PDBe 5T7O · UniProt Q4DLS1
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