UniProt Q49492
Mycinamicin III 3''-O-methyltransferase (Q49492)
Mycinamicin III 3''-O-methyltransferase (UniProt Q49492), EC 2.1.1.237: 18 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q49492
- Protein
- Mycinamicin III 3''-O-methyltransferase
- EC
- 2.1.1.237
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 7 · 4 records with a druggable one
Structures
19 records of Q49492 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4X7U | MycF mycinamicin III 3'-O-methyltransferase in complex with Mg, SAH and mycinamicin III (substrate) | x-ray diffraction | A, B | — | — |
| 4X7U | Mycf mycinamicin III 3'-O-methyltransferase in complex with mg, sah and mycinamicin III (substrate) | x-ray diffraction | A, B | — | — |
| 4X7V | MycF mycinamicin III 3'-O-methyltransferase (E35Q, E139A variant) in complex with Mg, SAH and… | x-ray diffraction | A, B | — | — |
| 4X7V | Mycf mycinamicin III 3'-O-methyltransferase (E35Q, E139A variant) in complex with mg, sah and… | x-ray diffraction | A, B | — | — |
| 4X7W | MycF mycinamicin III 3'-O-methyltransferase (E35Q, E139A variant) in complex with Mg, SAH and… | x-ray diffraction | A, B | — | — |
| 4X7W | Mycf mycinamicin III 3'-O-methyltransferase (E35Q, E139A variant) in complex with mg, sah and… | x-ray diffraction | A, B | — | — |
| 4X7X | MycF mycinamicin III 3'-O-methyltransferase (E35Q, E139A variant) in complex with Mg, SAH and… | x-ray diffraction | A, B | — | — |
| 4X7X | Mycf mycinamicin III 3'-O-methyltransferase (E35Q, E139A variant) in complex with mg, sah and… | x-ray diffraction | A, B | — | — |
| 4X7Y | MycF mycinamicin III 3'-O-methyltransferase (E35Q, M56A, E139A variant) in complex with Mg and SAH | x-ray diffraction | B, A | — | — |
| 4X7Y | Mycf mycinamicin III 3'-O-methyltransferase (E35Q, M56A, E139A variant) in complex with mg and sah | x-ray diffraction | B, A | — | — |
| 4X7Z | MycF mycinamicin III 3'-O-methyltransferase (E35Q, M56A, E139A variant) in complex with Mg, SAH and… | x-ray diffraction | A, B | SAH, MG, ZM3 | 2 (best 0.78) |
| 4X7Z | Mycf mycinamicin III 3'-O-methyltransferase (E35Q, M56A, E139A variant) in complex with mg, sah and… | x-ray diffraction | A, B | — | — |
| 4X81 | MycF mycinamicin III 3'-O-methyltransferase (E35Q, M56A, E139A variant) in complex with Mg, SAH and… | x-ray diffraction | A, B | SAH, MG, MVI | 2 (best 0.77) |
| 4X81 | Mycf mycinamicin III 3'-O-methyltransferase (E35Q, M56A, E139A variant) in complex with mg, sah and… | x-ray diffraction | A, B | — | — |
| 4XVY | MycF mycinamicin III 3'-O-methyltransferase in complex with SAH | x-ray diffraction | A, B | MG, SAH | 2 (best 0.75) |
| 4XVY | Mycf mycinamicin III 3'-O-methyltransferase in complex with sah | x-ray diffraction | A, B | — | — |
| 4XVZ | MycF mycinamicin III 3'-O-methyltransferase in complex with Mg | x-ray diffraction | A, B, C, D | — | — |
| 4XVZ | Mycf mycinamicin III 3'-O-methyltransferase in complex with mg | x-ray diffraction | A, B, C, D | — | — |
| Q49492 | AlphaFold monomer V2.0 prediction for mycinamicin III 3''-O-methyltransferase (Q49492) | predicted | A | — | 1 (best 0.76) |
Ligands
Experiment against prediction
- 4X81 chain A against the predicted model Q49492: TM-score 1.00, RMSD 0.13 Å
- 4X7Z chain B against the predicted model Q49492: TM-score 1.00, RMSD 0.14 Å
- 4X7Z chain A against the predicted model Q49492: TM-score 1.00, RMSD 0.15 Å
- 4XVY chain A against the predicted model Q49492: TM-score 1.00, RMSD 0.24 Å
- 4X81 chain A against the predicted model Q49492: TM-score 1.00, RMSD 0.13 Å
- 4X7V chain A against the predicted model Q49492: TM-score 1.00, RMSD 0.14 Å
- 4X7V chain A against the predicted model Q49492: TM-score 1.00, RMSD 0.14 Å
- 4X7Z chain B against the predicted model Q49492: TM-score 1.00, RMSD 0.14 Å
- 4X7W chain A against the predicted model Q49492: TM-score 1.00, RMSD 0.14 Å
- 4X7W chain A against the predicted model Q49492: TM-score 1.00, RMSD 0.14 Å
Elsewhere
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