UniProt Q46896
CRISPR-associated endonuclease Cas1 (Q46896)
CRISPR-associated endonuclease Cas1 (UniProt Q46896), EC 3.1.-.-: 28 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 131 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q46896
- Protein
- CRISPR-associated endonuclease Cas1
- EC
- 3.1.-.-
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 131 · 8 records with a druggable one
Structures
29 records of Q46896 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3NKE | High resolution structure of the C-terminal domain CRISP-associated protein Cas1 from Escherichia… | x-ray diffraction | A, B, C | — | — |
| 3NKE | High resolution structure of the C-terminal domain crisp-associated protein CAS1 from escherichia… | x-ray diffraction | A, B, C | — | — |
| 4P6I | Crystal structure of the Cas1-Cas2 complex from Escherichia coli | x-ray diffraction | C, D, E, F | — | — |
| 4P6I | Crystal structure of the CAS1-CAS2 complex from escherichia COLI | x-ray diffraction | C, D, E, F | — | — |
| 4QDL | Crystal structure of E.coli Cas1-Cas2 complex | x-ray diffraction | A, B, C, D | — | — |
| 4QDL | Crystal structure of E.COLI CAS1-CAS2 complex | x-ray diffraction | A, B, C, D | — | — |
| 5DLJ | Crystal Structure of Cas-DNA-N1 complex | x-ray diffraction | D, C, A, B | — | 15 (best 0.83) |
| 5DLJ | Crystal structure of CAS-DNA-N1 complex | x-ray diffraction | D, C, A, B | — | — |
| 5DQT | Crystal Structure of Cas-DNA-22 complex | x-ray diffraction | D, C, A, B, L, K, I, J | — | — |
| 5DQT | Crystal structure of CAS-DNA-22 complex | x-ray diffraction | D, C, A, B, L, K, I, J | — | — |
| 5DQU | Crystal Structure of Cas-DNA-10 complex | x-ray diffraction | A, D, C, B | — | 19 (best 0.81) |
| 5DQU | Crystal structure of CAS-DNA-10 complex | x-ray diffraction | A, D, C, B | — | — |
| 5DQZ | Crystal Structure of Cas-DNA-PAM complex | x-ray diffraction | D, C, A, B | MG | — |
| 5DQZ | Crystal structure of CAS-DNA-pam complex | x-ray diffraction | D, C, A, B | — | — |
| 5DS4 | Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA | x-ray diffraction | A, B, C, D | — | 14 (best 0.79) |
| 5DS4 | Crystal structure the escherichia COLI CAS1-CAS2 complex bound to protospacer DNA | x-ray diffraction | A, B, C, D | — | — |
| 5DS5 | Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA and Mg | x-ray diffraction | A, B, C, D | MG | 15 (best 0.81) |
| 5DS5 | Crystal structure the escherichia COLI CAS1-CAS2 complex bound to protospacer DNA and mg | x-ray diffraction | A, B, C, D | — | — |
| 5DS6 | Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA with splayed ends | x-ray diffraction | A, B, C, D | — | 19 (best 0.80) |
| 5DS6 | Crystal structure the escherichia COLI CAS1-CAS2 complex bound to protospacer DNA with splayed ends | x-ray diffraction | A, B, C, D | — | — |
| 5VVJ | Cas1-Cas2 bound to half-site intermediate | x-ray diffraction | A, B, C, D | — | 17 (best 0.81) |
| 5VVJ | CAS1-CAS2 bound to half-site intermediate | x-ray diffraction | A, B, C, D | — | — |
| 5VVK | Cas1-Cas2 bound to full-site mimic | x-ray diffraction | A, B, C, D | — | 19 (best 0.81) |
| 5VVK | CAS1-CAS2 bound to full-site mimic | x-ray diffraction | A, B, C, D | — | — |
| 5VVL | Cas1-Cas2 bound to full-site mimic with Ni | x-ray diffraction | A, B, C, D | NI | — |
| 5VVL | CAS1-CAS2 bound to full-site mimic with ni | x-ray diffraction | A, B, C, D | NI | — |
| 5WFE | Cas1-Cas2-IHF-DNA holo-complex | electron microscopy | A, B, C, D | — | 13 (best 0.82) |
| 5WFE | CAS1-CAS2-ihf-DNA holo-complex | electron microscopy | A, B, C, D | — | — |
| Q46896 | AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS1 (Q46896) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5DQZ chain C against the predicted model Q46896: TM-score 0.98, RMSD 0.94 Å
- 5DQZ chain C against the predicted model Q46896: TM-score 0.98, RMSD 0.94 Å
- 5DQZ chain B against the predicted model Q46896: TM-score 0.98, RMSD 0.95 Å
- 5DQZ chain B against the predicted model Q46896: TM-score 0.98, RMSD 0.95 Å
- 5DQU chain B against the predicted model Q46896: TM-score 0.98, RMSD 0.89 Å
- 5DQU chain B against the predicted model Q46896: TM-score 0.98, RMSD 0.89 Å
- 5DQT chain K against the predicted model Q46896: TM-score 0.98, RMSD 0.92 Å
- 5DQT chain K against the predicted model Q46896: TM-score 0.98, RMSD 0.92 Å
- 5DQT chain C against the predicted model Q46896: TM-score 0.98, RMSD 0.93 Å
- 5DQT chain C against the predicted model Q46896: TM-score 0.98, RMSD 0.93 Å
Elsewhere
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