UniProt Q460N3
Protein mono-ADP-ribosyltransferase PARP15 (Q460N3)
Protein mono-ADP-ribosyltransferase PARP15 (UniProt Q460N3), EC 2.4.2.-, 2.4.2.30: 71 experimental structures and 1 predicted model on GenesisL1, 36 ligands bound, 172 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q460N3
- Protein
- Protein mono-ADP-ribosyltransferase PARP15
- EC
- 2.4.2.-, 2.4.2.30
- Experimental structures
- 71
- Predicted models
- 1
- Ligands
- 36
- Pockets
- 172 · 35 records with a druggable one
Structures
72 records of Q460N3 in the MolNFT archive: 71 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3BLJ | Crystal structure of human poly(ADP-ribose) polymerase 15, catalytic fragment | x-ray diffraction | A, B | — | — |
| 3BLJ | Crystal structure of human POLY(ADP-ribose) polymerase 15, catalytic fragment | x-ray diffraction | A, B | — | — |
| 3GEY | Crystal structure of human poly(ADP-ribose) polymerase 15, catalytic fragment in complex with an… | x-ray diffraction | A, B, C, D | — | — |
| 3GEY | Crystal structure of human POLY(ADP-ribose) polymerase 15, catalytic fragment in complex with an… | x-ray diffraction | A, B, C, D | — | — |
| 3V2B | Human poly(adp-ribose) polymerase 15 (ARTD7, BAL3), macro domain 2 in complex with… | x-ray diffraction | A | — | — |
| 3V2B | Human POLY(ADP-ribose) polymerase 15 (ARTD7, BAL3), macro domain 2 in complex with… | x-ray diffraction | A | — | — |
| 4F0E | Human ADP-RIBOSYLTRANSFERASE 7 (ARTD7/PARP15), CATALYTIC DOMAIN IN COMPLEX WITH STO1102 | x-ray diffraction | A, B, C, D | — | — |
| 4F0E | Human ADP-ribosyltransferase 7 (ARTD7/PARP15), catalytic domain in complex with STO1102 | x-ray diffraction | A, B, C, D | — | — |
| 6EK3 | PARP15 catalytic domain mutant (Y598L) in complex with OUL35 | x-ray diffraction | A, B | OUL | 5 (best 0.78) |
| 6EK3 | PARP15 catalytic domain mutant (Y598L) in complex with OUL35 | x-ray diffraction | A, B | OUL | — |
| 6RY4 | PARP15 catalytic domain in complex with 4-(3-carbamoylphenoxy)benzamide. | x-ray diffraction | A, B | KMW | 5 (best 0.78) |
| 6RY4 | PARP15 catalytic domain in complex with 4-(3-carbamoylphenoxy) benzamide. | x-ray diffraction | A, B | KMW | — |
| 7F41 | PARP15 catalytic domain in complex with 3-AMINOBENZAMIDE | x-ray diffraction | A, B | 3AB | 4 (best 0.80) |
| 7F41 | PARP15 catalytic domain in complex with 3-aminobenzamide | x-ray diffraction | A, B | 3AB | — |
| 7F42 | PARP15 catalytic domain in complex with Iniparib | x-ray diffraction | B, A | 33E | 5 (best 0.78) |
| 7F42 | PARP15 catalytic domain in complex with iniparib | x-ray diffraction | B, A | 33E | — |
| 7F43 | PARP15 catalytic domain in complex with Niraparib | x-ray diffraction | A, B | 3JD | 4 (best 0.79) |
| 7F43 | PARP15 catalytic domain in complex with niraparib | x-ray diffraction | A, B | 3JD | — |
| 7OQQ | PARP15 catalytic domain in complex with TIQ-A | x-ray diffraction | A, B | G18 | 4 (best 0.84) |
| 7OQQ | PARP15 catalytic domain in complex with tiq-a | x-ray diffraction | A, B | G18 | — |
| 7OSP | PARP15 catalytic domain in complex with OUL113 | x-ray diffraction | A, B | 0Q6 | 6 (best 0.77) |
| 7OSP | PARP15 catalytic domain in complex with OUL113 | x-ray diffraction | A, B | 0Q6 | — |
| 7OSS | PARP15 catalytic domain in complex with OUL194 | x-ray diffraction | A, B | 0SI | 5 (best 0.77) |
| 7OSS | PARP15 catalytic domain in complex with OUL194 | x-ray diffraction | A, B | 0SI | — |
| 7OSX | PARP15 catalytic domain in complex with OUL205 | x-ray diffraction | A, B | 0UI | 4 (best 0.78) |
| 7OSX | PARP15 catalytic domain in complex with OUL205 | x-ray diffraction | A, B | 0UI | — |
| 7OTF | PARP15 catalytic domain in complex with OUL213 | x-ray diffraction | A, B | 1H9 | 5 (best 0.76) |
| 7OTF | PARP15 catalytic domain in complex with OUL213 | x-ray diffraction | A, B | 1H9 | — |
| 7OTH | PARP15 catalytic domain in complex with OUL219 | x-ray diffraction | A, B | VJN | 5 (best 0.78) |
| 7OTH | PARP15 catalytic domain in complex with OUL219 | x-ray diffraction | A, B | VJN | — |
| 7OUW | PARP15 catalytic domain in complex with OUL220 | x-ray diffraction | A, B | 1OI | 6 (best 0.78) |
| 7OUW | PARP15 catalytic domain in complex with OUL220 | x-ray diffraction | A, B | 1OI | — |
| 7OUX | PARP15 catalytic domain in complex with OUL228 | x-ray diffraction | A, B | 1O7 | 5 (best 0.78) |
| 7OUX | PARP15 catalytic domain in complex with OUL228 | x-ray diffraction | A, B | 1O7 | — |
| 7PW3 | PARP15 catalytic domain in complex with OUL217 | x-ray diffraction | A, B | 8C7 | 5 (best 0.80) |
| 7PW3 | PARP15 catalytic domain in complex with OUL217 | x-ray diffraction | A, B | 8C7 | — |
| 7PWA | PARP15 catalytic domain in complex with OUL237 | x-ray diffraction | A, B | 8CI | 4 (best 0.79) |
| 7PWA | PARP15 catalytic domain in complex with OUL237 | x-ray diffraction | A, B | 8CI | — |
| 7PWC | PARP15 catalytic domain in complex with OUL238 | x-ray diffraction | A, B | 8AE | 5 (best 0.79) |
| 7PWC | PARP15 catalytic domain in complex with OUL238 | x-ray diffraction | A, B | 8AE | — |
| 7PWK | PARP15 catalytic domain in complex with OUL239 | x-ray diffraction | A, B | 89Q | 5 (best 0.77) |
| 7PWK | PARP15 catalytic domain in complex with OUL239 | x-ray diffraction | A, B | 89Q | — |
| 7PWL | PARP15 catalytic domain in complex with OUL218 | x-ray diffraction | A, B | 8BK | 5 (best 0.78) |
| 7PWL | PARP15 catalytic domain in complex with OUL218 | x-ray diffraction | A, B | 8BK | — |
| 7PWM | PARP15 catalytic domain in complex with OUL252 | x-ray diffraction | A, B | 8AQ | 5 (best 0.79) |
| 7PWM | PARP15 catalytic domain in complex with OUL252 | x-ray diffraction | A, B | 8AQ | — |
| 7PWP | PARP15 catalytic domain in complex with OUL221 | x-ray diffraction | A, B | 8BE | 5 (best 0.80) |
| 7PWP | PARP15 catalytic domain in complex with OUL221 | x-ray diffraction | A, B | 8BE | — |
| 7PWQ | PARP15 catalytic domain in complex with OUL240 | x-ray diffraction | A, B | 8A8 | 5 (best 0.80) |
| 7PWQ | PARP15 catalytic domain in complex with OUL240 | x-ray diffraction | A, B | 8A8 | — |
| 7PWR | PARP15 catalytic domain in complex with OUL254 | x-ray diffraction | A, B | 89Z | 5 (best 0.79) |
| 7PWR | PARP15 catalytic domain in complex with OUL254 | x-ray diffraction | A, B | 89Z | — |
| 7PWS | PARP15 catalytic domain in complex with OUL255 | x-ray diffraction | A, B | 8BW | 5 (best 0.77) |
| 7PWS | PARP15 catalytic domain in complex with OUL255 | x-ray diffraction | A, B | 8BW | — |
| 7PWU | PARP15 catalytic domain in complex with OUL256 | x-ray diffraction | A, B | 89H | 5 (best 0.79) |
| 7PWU | PARP15 catalytic domain in complex with OUL256 | x-ray diffraction | A, B | 89H | — |
| 7PWW | PARP15 catalytic domain in complex with OUL224 | x-ray diffraction | A, B | 8B5 | 5 (best 0.78) |
| 7PWW | PARP15 catalytic domain in complex with OUL224 | x-ray diffraction | A, B | 8B5 | — |
| 7PX6 | PARP15 catalytic domain in complex with OUL241 | x-ray diffraction | A, B | 8D2 | — |
| 7PX6 | PARP15 catalytic domain in complex with OUL241 | x-ray diffraction | A, B | 8D2 | — |
12 records more on the page itself.
Ligands
- 0Q6 · 4-[(3-bromophenyl)methoxy]benzamide · in 2 records
- 0SI · 8-phenylmethoxy-4~{H}-thieno[2,3-c]isoquinolin-5-one · in 2 records
- 0UI · 8-oxidanyl-4~{H}-thieno[2,3-c]isoquinolin-5-one · in 2 records
- 1H9 · 8-[(3-bromophenyl)methoxy]-4~{H}-thieno[2,3-c]isoquinolin-5-one · in 2 records
- 1O7 · 8-ethoxy-4~{H}-thieno[2,3-c]isoquinolin-5-one · in 2 records
- 1OI · 8-methoxy-4~{H}-thieno[2,3-c]isoquinolin-5-one · in 2 records
- 33E · 4-iodo-3-nitrobenzamide · in 2 records
- 3AB · 3-aminobenzamide · in 2 records
- 3JD · 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide · in 2 records
- 89H · 6-(cyclopropylmethoxy)phthalazine-1,4-dione · in 2 records
- 89Q · 4-(cyclopropylmethoxy)benzamide · in 2 records
- 89Z · 6-(cyclopentylmethoxy)phthalazine-1,4-dione · in 2 records
- 8A8 · 6-(cyclohexylmethoxy)phthalazine-1,4-dione · in 2 records
- 8AE · 4-(cyclobutylmethoxy)benzamide · in 2 records
- 8AQ · 4-(cyclohexylmethoxy)-2-methoxy-benzamide · in 2 records
- 8B5 · 6-[(3-bromophenyl)methoxy]phthalazine-1,4-dione · in 2 records
- 8BE · 4-[(3-bromophenyl)methoxy]-2-methoxy-benzamide · in 2 records
- 8BK · 4-(1,3-thiazol-5-ylmethoxy)benzamide · in 2 records
- 8BW · 6-(cyclobutylmethoxy)phthalazine-1,4-dione · in 2 records
- 8C7 · 4-(cyclohexylmethoxy)benzamide · in 2 records
- 8CI · 4-(cyclopentylmethoxy)benzamide · in 2 records
- 8D2 · 6-[(2-fluorophenyl)methoxy]phthalazine-1,4-dione · in 2 records
- 8DB · 6-(thiophen-2-ylmethoxy)phthalazine-1,4-dione · in 2 records
- G18 · 4H-thieno[2,3-c]isoquinolin-5-one · in 2 records
- KMW · 3-(4-aminocarbonylphenoxy)benzamide · in 2 records
- OUL · 4-(4-aminocarbonylphenoxy)benzamide · in 2 records
- VJN · 8-propan-2-yloxy-4~{H}-thieno[2,3-c]isoquinolin-5-one · in 2 records
- I1B · 6,8-dimethyl-[1,2,4]triazolo[3,4-b][1,3]benzothiazole · in 1 record
- I1Q · 6-methyl-[1,2,4]triazolo[3,4-b][1,3]benzothiazole · in 1 record
- I4X · 6-propan-2-yl-[1,2,4]triazolo[3,4-b][1,3]benzothiazole · in 1 record
Experiment against prediction
- 7PWA chain A against the predicted model Q460N3: TM-score 1.00, RMSD 0.29 Å
- 7PWS chain A against the predicted model Q460N3: TM-score 1.00, RMSD 0.30 Å
- 7PWW chain A against the predicted model Q460N3: TM-score 1.00, RMSD 0.30 Å
- 7OSP chain A against the predicted model Q460N3: TM-score 1.00, RMSD 0.30 Å
- 7PW3 chain A against the predicted model Q460N3: TM-score 1.00, RMSD 0.30 Å
- 7PX6 chain A against the predicted model Q460N3: TM-score 1.00, RMSD 0.30 Å
- 7Z2Q chain A against the predicted model Q460N3: TM-score 1.00, RMSD 0.30 Å
- 7PWM chain A against the predicted model Q460N3: TM-score 1.00, RMSD 0.31 Å
- 7PX7 chain A against the predicted model Q460N3: TM-score 1.00, RMSD 0.31 Å
- 7PWP chain A against the predicted model Q460N3: TM-score 1.00, RMSD 0.31 Å
Elsewhere
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