UniProt Q3MHW7
Sigma intracellular receptor 2 (Q3MHW7)
Sigma intracellular receptor 2 (UniProt Q3MHW7): 10 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 104 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q3MHW7
- Protein
- Sigma intracellular receptor 2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 104 · 11 records with a druggable one
Structures
11 records of Q3MHW7 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7M93 | Bovine sigma-2 receptor bound to PB28 | x-ray diffraction | A, B, C, D | YT1 | 12 (best 0.73) |
| 7M93 | Bovine sigma-2 receptor bound to PB28 | x-ray diffraction | A, B, C, D | YT1 | 12 (best 0.73) |
| 7M94 | Bovine sigma-2 receptor bound to Roluperidone | x-ray diffraction | A, B, C, D | YT7 | 12 (best 0.72) |
| 7M94 | Bovine sigma-2 receptor bound to roluperidone | x-ray diffraction | A, B, C, D | YT7 | 12 (best 0.72) |
| 7M95 | Bovine sigma-2 receptor bound to Z1241145220 | x-ray diffraction | A, B | ZNC, CLR | 5 (best 0.71) |
| 7M95 | Bovine sigma-2 receptor bound to Z1241145220 | x-ray diffraction | A, B | ZNC, CLR | 5 (best 0.71) |
| 7M96 | Bovine sigma-2 receptor bound to Z4857158944 | x-ray diffraction | A, B, C, D | YTD | 11 (best 0.72) |
| 7M96 | Bovine sigma-2 receptor bound to Z4857158944 | x-ray diffraction | A, B, C, D | YTD | 11 (best 0.72) |
| 7MFI | Bovine sigma-2 receptor bound to cholesterol | x-ray diffraction | A, B, C, D | CLR | 11 (best 0.73) |
| 7MFI | Bovine sigma-2 receptor bound to cholesterol | x-ray diffraction | A, B, C, D | CLR | 11 (best 0.73) |
| Q3MHW7 | AlphaFold monomer V2.0 prediction for sigma intracellular receptor 2 (Q3MHW7) | predicted | A | — | 2 (best 0.70) |
Ligands
- CLR · Cholesterol · in 4 records
- YT1 · PB28 · in 2 records
- YT7 · Roluperidone · in 2 records
- YTD · 6-({[(1S)-1-hydroxy-2-methyl-1-phenylpropan-2-yl]amino}methyl)-1-methyl-3,4-dihydroquinolin-2(1H)-one · in 2 records
- ZNC · 3-[1-(3-phenylpropyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine · in 2 records
Experiment against prediction
- 7M94 chain B against the predicted model Q3MHW7: TM-score 0.99, RMSD 0.51 Å
- 7M94 chain B against the predicted model Q3MHW7: TM-score 0.99, RMSD 0.51 Å
- 7MFI chain B against the predicted model Q3MHW7: TM-score 0.98, RMSD 0.77 Å
- 7MFI chain B against the predicted model Q3MHW7: TM-score 0.98, RMSD 0.77 Å
- 7M94 chain D against the predicted model Q3MHW7: TM-score 0.98, RMSD 0.94 Å
- 7M94 chain D against the predicted model Q3MHW7: TM-score 0.98, RMSD 0.94 Å
- 7M93 chain D against the predicted model Q3MHW7: TM-score 0.98, RMSD 0.72 Å
- 7M93 chain D against the predicted model Q3MHW7: TM-score 0.98, RMSD 0.72 Å
- 7MFI chain A against the predicted model Q3MHW7: TM-score 0.98, RMSD 0.83 Å
- 7MFI chain A against the predicted model Q3MHW7: TM-score 0.98, RMSD 0.83 Å
Elsewhere
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