UniProt Q183R7
Pro-Pro endopeptidase (Q183R7)
Pro-Pro endopeptidase (UniProt Q183R7), EC 3.4.24.-, 3.4.24.89: 38 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q183R7
- Protein
- Pro-Pro endopeptidase
- EC
- 3.4.24.-, 3.4.24.89
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 15 · 8 records with a druggable one
Structures
39 records of Q183R7 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N6J | Solution structure of Zmp1, a zinc-dependent metalloprotease secreted by Clostridium difficile | solution nmr | A | — | — |
| 2N6J | Solution structure of ZMP1, a zinc-dependent metalloprotease secreted by clostridium difficile | solution nmr | A | — | — |
| 5A0P | Apo-structure of metalloprotease Zmp1 from Clostridium difficile | x-ray diffraction | A, B | — | — |
| 5A0P | Apo-structure of metalloprotease ZMP1 from clostridium difficile | x-ray diffraction | A, B | — | — |
| 5A0R | Product peptide-bound structure of metalloprotease Zmp1 variant E143A from Clostridium difficile | x-ray diffraction | A, B | ZN | 1 (best 0.76) |
| 5A0R | Product peptide-bound structure of metalloprotease ZMP1 variant E143A from clostridium difficile | x-ray diffraction | A, B | — | — |
| 5A0S | Apo-structure of metalloprotease Zmp1 variant E143A from Clostridium difficile | x-ray diffraction | A, B | — | — |
| 5A0S | Apo-structure of metalloprotease ZMP1 variant E143A from clostridium difficile | x-ray diffraction | A, B | — | — |
| 5A0X | Substrate peptide-bound structure of metalloprotease Zmp1 variant E143AY178F from Clostridium… | x-ray diffraction | A, B | ZN | 1 (best 0.50) |
| 5A0X | Substrate peptide-bound structure of metalloprotease ZMP1 variant E143AY178F from clostridium… | x-ray diffraction | A, B | — | — |
| 5N12 | Crystal structure of tce treated rppep-1 | x-ray diffraction | A, B | ZN, 8FH | — |
| 6R4W | Crystal structure of apo PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVNAPVP-CONH2 | x-ray diffraction | A, B | ZN | — |
| 6R4W | Crystal structure of apo ppep-1(E143A/Y178F) in complex with substrate peptide ac-evnapvp-CONH2 | x-ray diffraction | A, B | ACE, ZN | — |
| 6R4X | Crystal structure of ppep-1(E143A/Y178F) in complex with substrate peptide ac-evnpavp-CONH2 | x-ray diffraction | A, B | ACE, ZN | — |
| 6R4Y | Crystal structure of holo PPEP-1(E143A/Y178F) in complex with product peptide Ac-EVNP-CO2… | x-ray diffraction | A, B | ZN | 1 (best 0.74) |
| 6R4Y | Crystal structure of holo ppep-1(E143A/Y178F) in complex with product peptide ac-evnp-CO2… | x-ray diffraction | A, B | ACE, ZN | — |
| 6R4Z | Crystal structure of holo PPEP-1(E143A/Y178F) in complex with product peptide Ac-EVNP-CO2… | x-ray diffraction | A, B | ZN, NI | 2 (best 0.75) |
| 6R4Z | Crystal structure of holo ppep-1(E143A/Y178F) in complex with product peptide ac-evnp-CO2… | x-ray diffraction | A, B | ACE, ZN, NI | — |
| 6R50 | Crystal structure of holo ppep-1(E143A/Y178F) in complex with substrate peptide ac-evnapvp-CONH2 | x-ray diffraction | A, B | ACE, ZN | — |
| 6R51 | Crystal structure of apo PPEP-1(E143A/Y178F) in complex with fibrinogen-derived substrate peptide… | x-ray diffraction | B, A, C | PO4 | 3 (best 0.70) |
| 6R51 | Crystal structure of apo ppep-1(E143A/Y178F) in complex with fibrinogen-derived substrate peptide… | x-ray diffraction | B, A, C | ACE, PO4 | — |
| 6R52 | Crystal structure of ppep-1(K101A) | x-ray diffraction | A, B | ZN | — |
| 6R53 | Crystal structure of ppep-1(K101R) | x-ray diffraction | A, B | ZN | — |
| 6R54 | Crystal structure of PPEP-1(E184A) | x-ray diffraction | A, B | ZN, NI | — |
| 6R54 | Crystal structure of ppep-1(E184A) | x-ray diffraction | A, B | ZN, NI | — |
| 6R55 | Crystal structure of ppep-1(E184K) | x-ray diffraction | A, B | ZN | — |
| 6R56 | Crystal structure of PPEP-1(K101E/E184K) | x-ray diffraction | A, B | ZN | 2 (best 0.74) |
| 6R56 | Crystal structure of ppep-1(K101E/E184K) | x-ray diffraction | A, B | ZN | — |
| 6R57 | Crystal structure of ppep-1(E143A/Y178F/E184A) in complex with substrate peptide ac-evnppvp-CONH2 | x-ray diffraction | A, B | ACE, ZN | — |
| 6R58 | Crystal structure of ppep-1(E143A/Y178F/E184A) in complex with substrate peptide ac-evnapvp-CONH2 | x-ray diffraction | A, B, C, D | ACE, ZN, PO4, NI | — |
| 6R59 | Crystal structure of PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVAPPVP-NH2 | x-ray diffraction | A, B | ZN | 1 (best 0.50) |
| 6R59 | Crystal structure of ppep-1(E143A/Y178F) in complex with substrate peptide ac-evappvp-NH2 | x-ray diffraction | A, B | ACE, ZN | — |
| 6R5A | Crystal structure of PPEP-1(W103F) | x-ray diffraction | A, B | ZN | — |
| 6R5A | Crystal structure of ppep-1(W103F) | x-ray diffraction | A, B | ZN | — |
| 6R5B | Crystal structure of PPEP-1(W103H/E143A/Y178F) in complex with substrate peptide Ac-EVNPPVP-CONH2 | x-ray diffraction | A, B | — | 1 (best 0.43) |
| 6R5B | Crystal structure of ppep-1(W103H/E143A/Y178F) in complex with substrate peptide ac-evnppvp-CONH2 | x-ray diffraction | A, B | ACE | — |
| 6R5C | Crystal structure of PPEP-1(W103F/E143A/Y178F) in complex with substrate peptide Ac-EVNPPVP-CONH2 | x-ray diffraction | A, B | ZN | 1 (best 0.50) |
| 6R5C | Crystal structure of ppep-1(W103F/E143A/Y178F) in complex with substrate peptide ac-evnppvp-CONH2 | x-ray diffraction | A, B | ACE, ZN | — |
| Q183R7 | AlphaFold monomer V2.0 prediction for pro-pro endopeptidase (Q183R7) | predicted | A | — | 2 (best 0.62) |
Ligands
Experiment against prediction
- 6R55 chain B against the predicted model Q183R7: TM-score 1.00, RMSD 0.30 Å
- 6R4Y chain A against the predicted model Q183R7: TM-score 1.00, RMSD 0.32 Å
- 6R4Y chain A against the predicted model Q183R7: TM-score 1.00, RMSD 0.32 Å
- 5A0R chain A against the predicted model Q183R7: TM-score 1.00, RMSD 0.33 Å
- 5A0R chain A against the predicted model Q183R7: TM-score 1.00, RMSD 0.33 Å
- 6R5C chain B against the predicted model Q183R7: TM-score 1.00, RMSD 0.34 Å
- 6R5C chain B against the predicted model Q183R7: TM-score 1.00, RMSD 0.34 Å
- 6R5C chain A against the predicted model Q183R7: TM-score 0.99, RMSD 0.37 Å
- 6R5C chain A against the predicted model Q183R7: TM-score 0.99, RMSD 0.37 Å
- 5A0X chain A against the predicted model Q183R7: TM-score 0.99, RMSD 0.39 Å
Elsewhere
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