UniProt Q16875
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (Q16875)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (UniProt Q16875), EC 2.7.1.105, 3.1.3.46: 51 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 13 pockets. Binding sites, druggability and…
- UniProt
- Q16875
- Protein
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
- EC
- 2.7.1.105, 3.1.3.46
- Experimental structures
- 51
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 13 · 4 records with a druggable one
Structures
52 records of Q16875 in the MolNFT archive: 51 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AXN | Crystal structure of the human inducible form 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | x-ray diffraction | A | — | — |
| 2AXN | Crystal structure of the human inducible form 6-phosphofructo-2- KINASE/FRUCTOSE-2,6-bisphosphatase | x-ray diffraction | A | — | — |
| 2DWO | PFKFB3 in complex with ADP and PEP | x-ray diffraction | A | — | — |
| 2DWO | PFKFB3 in complex with ADP and pep | x-ray diffraction | A | — | — |
| 2DWP | A pseudo substrate complex of 6-phosphofructo-2-kinase of PFKFB | x-ray diffraction | A | — | — |
| 2DWP | A pseudo substrate complex of 6-phosphofructo-2-kinase of pfkfb | x-ray diffraction | A | — | — |
| 2I1V | Crystal structure of PFKFB3 in complex with ADP and Fructose-2,6-bisphosphate | x-ray diffraction | B | — | — |
| 2I1V | Crystal structure of PFKFB3 in complex with ADP and fructose-2,6- bisphosphate | x-ray diffraction | B | — | — |
| 3QPU | PFKFB3 in complex with PPi | x-ray diffraction | A | — | — |
| 3QPU | PFKFB3 in complex with ppi | x-ray diffraction | A | — | — |
| 3QPV | PFKFB3 trapped in a phospho-enzyme intermediate state | x-ray diffraction | A | — | — |
| 3QPV | PFKFB3 trapped in a phospho-enzyme intermediate state | x-ray diffraction | A | — | — |
| 3QPW | PFKFB3 in complex with Aluminum Tetrafluoride | x-ray diffraction | A | — | — |
| 3QPW | PFKFB3 in complex with aluminum tetrafluoride | x-ray diffraction | A | — | — |
| 4D4J | human PFKFB3 in complex with a pyrrolopyrimidone compound | x-ray diffraction | A | — | — |
| 4D4J | Human PFKFB3 in complex with a pyrrolopyrimidone compound | x-ray diffraction | A | — | — |
| 4D4K | human PFKFB3 in complex with a pyrrolopyrimidone compound | x-ray diffraction | A | — | — |
| 4D4K | Human PFKFB3 in complex with a pyrrolopyrimidone compound | x-ray diffraction | A | — | — |
| 4D4L | human PFKFB3 in complex with a pyrrolopyrimidone compound | x-ray diffraction | A | — | — |
| 4D4L | Human PFKFB3 in complex with a pyrrolopyrimidone compound | x-ray diffraction | A | — | — |
| 4D4M | human PFKFB3 in complex with a pyrrolopyrimidone compound | x-ray diffraction | A | — | — |
| 4D4M | Human PFKFB3 in complex with a pyrrolopyrimidone compound | x-ray diffraction | A | — | — |
| 4MA4 | S-glutathionylated PFKFB3 | x-ray diffraction | A | — | — |
| 4MA4 | S-glutathionylated PFKFB3 | x-ray diffraction | A | — | — |
| 5AJV | Human PFKFB3 in complex with an indole inhibitor 1 | x-ray diffraction | B | — | — |
| 5AJV | Human PFKFB3 in complex with an indole inhibitor 1 | x-ray diffraction | B | — | — |
| 5AJW | Human PFKFB3 in complex with an indole inhibitor 2 | x-ray diffraction | A | — | — |
| 5AJW | Human PFKFB3 in complex with an indole inhibitor 2 | x-ray diffraction | A | — | — |
| 5AJX | Human PFKFB3 in complex with an indole inhibitor 3 | x-ray diffraction | A | — | — |
| 5AJX | Human PFKFB3 in complex with an indole inhibitor 3 | x-ray diffraction | A | — | — |
| 5AJY | Human PFKFB3 in complex with an indole inhibitor 4 | x-ray diffraction | A | — | — |
| 5AJY | Human PFKFB3 in complex with an indole inhibitor 4 | x-ray diffraction | A | — | — |
| 5AJZ | Human PFKFB3 in complex with an indole inhibitor 5 | x-ray diffraction | A | — | — |
| 5AJZ | Human PFKFB3 in complex with an indole inhibitor 5 | x-ray diffraction | A | — | — |
| 5AK0 | Human PFKFB3 in complex with an indole inhibitor 6 | x-ray diffraction | A | — | — |
| 5AK0 | Human PFKFB3 in complex with an indole inhibitor 6 | x-ray diffraction | A | — | — |
| 6ETJ | Human PFKFB3 in complex with KAN0438241 | x-ray diffraction | A | F6P, BWW, ADP | — |
| 6HVH | Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 1 | x-ray diffraction | A | GV2, POP, F6P | — |
| 6HVH | Human PFKFB3 in complex with a N-aryl 6-aminoquinoxaline inhibitor 1 | x-ray diffraction | A | GV2, POP, F6P | — |
| 6HVI | Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 2 | x-ray diffraction | A | GV5, POP, F6P | — |
| 6HVI | Human PFKFB3 in complex with a N-aryl 6-aminoquinoxaline inhibitor 2 | x-ray diffraction | A | GV5, POP, F6P | — |
| 6HVJ | Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 3 | x-ray diffraction | A | GV8, F6P, PO4 | — |
| 6HVJ | Human PFKFB3 in complex with a N-aryl 6-aminoquinoxaline inhibitor 3 | x-ray diffraction | A | GV8, F6P, PO4 | — |
| 6IBX | Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 5 | x-ray diffraction | A | H9Z, POP, F6P | 3 (best 0.83) |
| 6IBX | Human PFKFB3 in complex with a N-aryl 6-aminoquinoxaline inhibitor 5 | x-ray diffraction | A | H9Z, POP, F6P | — |
| 6IBY | Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 6 | x-ray diffraction | A | HAT, POP, F6P, PO4 | 4 (best 0.82) |
| 6IBY | Human PFKFB3 in complex with a N-aryl 6-aminoquinoxaline inhibitor 6 | x-ray diffraction | A | HAT, POP, F6P, PO4 | — |
| 6IBZ | Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 7 | x-ray diffraction | A | PO4, HAW, F6P | 3 (best 0.82) |
| 6IBZ | Human PFKFB3 in complex with a N-aryl 6-aminoquinoxaline inhibitor 7 | x-ray diffraction | A | PO4, HAW, F6P | — |
| 6IC0 | Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 4 | x-ray diffraction | A | HAK, POP, F6P | 3 (best 0.82) |
| 6IC0 | Human PFKFB3 in complex with a N-aryl 6-aminoquinoxaline inhibitor 4 | x-ray diffraction | A | HAK, POP, F6P | — |
| Q16875 | AlphaFold monomer V2.0 prediction for 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-bisphosphatase 3… | predicted | A | — | — |
Ligands
- F6P · 6-O-phosphono-beta-D-fructofuranose · in 15 records
- POP · Pyrophosphate 2- · in 10 records
- PO4 · Phosphate ion · in 6 records
- GV2 · 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-(oxan-4-yl)pyridine-4-carboxamide · in 2 records
- GV5 · 8-[3-(dimethylamino)phenyl]-~{N}-(4-methylsulfonylpyridin-3-yl)quinoxalin-6-amine · in 2 records
- GV8 · 8-(3-methyl-1-benzofuran-5-yl)-~{N}-(4-methylsulfonylpyridin-3-yl)quinoxalin-6-amine · in 2 records
- H9Z · 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpiperidin-3-yl]pyridine-4-carboxamide · in 2 records
- HAK · 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-pyrimidin-5-yl-pyridine-4-carboxamide · in 2 records
- HAT · 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpyrrolidin-3-yl]pyridine-4-carboxamide · in 2 records
- HAW · 2-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-(pyrimidin-5-ylmethyl)benzenesulfonamide · in 2 records
- ADP · Adenosine-5'-diphosphate · in 1 record
- BWW · 4-[[3-(5-fluoranyl-2-oxidanyl-phenyl) phenyl]sulfonylamino]-2-oxidanyl-benzoic acid · in 1 record
Experiment against prediction
- 6ETJ chain A against the predicted model Q16875: TM-score 0.99, RMSD 0.58 Å
- 4D4J chain A against the predicted model Q16875: TM-score 0.99, RMSD 0.57 Å
- 4D4J chain A against the predicted model Q16875: TM-score 0.99, RMSD 0.57 Å
- 4D4K chain A against the predicted model Q16875: TM-score 0.99, RMSD 0.57 Å
- 4D4K chain A against the predicted model Q16875: TM-score 0.99, RMSD 0.57 Å
- 5AJZ chain A against the predicted model Q16875: TM-score 0.99, RMSD 0.60 Å
- 5AJZ chain A against the predicted model Q16875: TM-score 0.99, RMSD 0.60 Å
- 4D4M chain A against the predicted model Q16875: TM-score 0.99, RMSD 0.62 Å
- 4D4M chain A against the predicted model Q16875: TM-score 0.99, RMSD 0.62 Å
- 5AJW chain A against the predicted model Q16875: TM-score 0.99, RMSD 0.62 Å
Elsewhere
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