MolNFT v1 · #31517 · protein
Crystal structure of the human inducible form 6-phosphofructo-2- KINASE/FRUCTOSE-2,6-bisphosphatase
2AXN · 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-biphosphatase 3 (6PF…: “Crystal structure of the human inducible form 6-phosphofructo-2- KINASE/FRUCTOSE-2,6-bisphosphatase”. X-ray diffraction, 3 ligands (F6P, EDT, ADP), 3 pockets (best…
- PDB
- 2AXN
- Type
- protein
- Length
- 451 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-biphosphatase 3 (6PF- 2-K/FRU- 2,6-P2ASE…
- UniProt
- Q16875
- Ligands
- F6P, EDT, ADP
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-biphosphatase 3 (6PF- 2-K/FRU- 2,6-P2ASE BRAIN/PLACENTA-type isozyme) (ipfk-2) [includes: 6- phosphofructo-2-kinase (ec 2.7.1.105) | protein | 451 | 43% helix, 17% strand | Q16875 |
Ligands and binding sites
- F6P · 6-O-phosphono-beta-D-fructofuranose · ligand · chains A
- EDT · {[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid · ligand · chains A
- ADP · Adenosine-5'-diphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 632 | 0.83 | 0.88 | 80 | EDT, ADP |
| 2 | 149 | 0.73 | 0.92 | 33 | F6P |
| 3 | 63 | 0.61 | 0.91 | 15 | empty |
Compared structures
- 2AXN · Crystal structure of the human inducible form 6-phosphofructo-2-kinase/fructose-2,6-bispho… · the same entry in another collection · chain A against A, TM-score 1.00
- Q16875 · AlphaFold monomer V2.0 prediction for 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-bisphosphatase… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16875
- Elsewhere: RCSB PDB 2AXN · PDBe 2AXN · UniProt Q16875
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