UniProt Q16774
Guanylate kinase (Q16774)
Guanylate kinase (UniProt Q16774), EC 2.7.4.8: 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q16774
- Protein
- Guanylate kinase
- EC
- 2.7.4.8
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 5 · 1 record with a druggable one
Structures
4 records of Q16774 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6NUI | Human Guanylate Kinase | solution nmr | A | — | 1 (best 0.32) |
| 6NUI | Human guanylate kinase | solution nmr | A | — | — |
| 8PTS | human GUK1 in complex with compound AT8001 | x-ray diffraction | A, B | EIF | 4 (best 0.79) |
| Q16774 | AlphaFold monomer V2.0 prediction for guanylate kinase (Q16774) | predicted | A | — | — |
Ligands
- EIF · [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate · in 1 record
Experiment against prediction
- 8PTS chain A against the predicted model Q16774: TM-score 0.78, RMSD 3.06 Å
- 8PTS chain B against the predicted model Q16774: TM-score 0.77, RMSD 3.25 Å
- 6NUI chain A against the predicted model Q16774: TM-score 0.73, RMSD 3.33 Å
- 6NUI chain A against the predicted model Q16774: TM-score 0.73, RMSD 3.33 Å
Elsewhere
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