UniProt Q16659
Mitogen-activated protein kinase 6 (Q16659)
Mitogen-activated protein kinase 6 (UniProt Q16659), EC 2.7.11.24: 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 42 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q16659
- Protein
- Mitogen-activated protein kinase 6
- EC
- 2.7.11.24
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 42 · 4 records with a druggable one
Structures
9 records of Q16659 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6YKY | Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors | x-ray diffraction | A, B, C, D | OWQ | 18 (best 0.85) |
| 6YKY | Biochemical, cellular and structural characterization of novel ERK3 inhibitors | x-ray diffraction | A, B, C, D | OWQ | — |
| 6YLC | Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors | x-ray diffraction | A, B, C, D | OXW | 14 (best 0.84) |
| 6YLC | Biochemical, cellular and structural characterization of novel ERK3 inhibitors | x-ray diffraction | A, B, C, D | OXW | — |
| 6YLL | Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors | x-ray diffraction | A, B | OYB | 6 (best 0.82) |
| 6YLL | Biochemical, cellular and structural characterization of novel ERK3 inhibitors | x-ray diffraction | A, B | OYB | — |
| 7AQB | Crystal structure of human mitogen activated protein kinase 6 (MAPK6) | x-ray diffraction | A, B | MG | 4 (best 0.78) |
| 7AQB | Crystal structure of human mitogen activated protein kinase 6 (MAPK6) | x-ray diffraction | A, B | MG | — |
| Q16659 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 6 (Q16659) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 2 records
- OWQ · 3-(4-methoxyphenyl)-~{N}-[(3~{R})-1-pyridin-4-ylpyrrolidin-3-yl]-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine · in 2 records
- OXW · 5-fluoranyl-2-[5-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]benzenecarbonitrile · in 2 records
- OYB · ~{N}4-[3-(4-methoxyphenyl)-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]cyclohexane-1,4-diamine · in 2 records
Experiment against prediction
- 6YLC chain A against the predicted model Q16659: TM-score 0.96, RMSD 1.51 Å
- 6YLC chain A against the predicted model Q16659: TM-score 0.96, RMSD 1.51 Å
- 6YKY chain C against the predicted model Q16659: TM-score 0.96, RMSD 1.49 Å
- 6YKY chain C against the predicted model Q16659: TM-score 0.96, RMSD 1.49 Å
- 6YLL chain B against the predicted model Q16659: TM-score 0.96, RMSD 1.16 Å
- 6YLL chain B against the predicted model Q16659: TM-score 0.96, RMSD 1.16 Å
- 6YLC chain B against the predicted model Q16659: TM-score 0.96, RMSD 1.27 Å
- 6YLC chain B against the predicted model Q16659: TM-score 0.96, RMSD 1.27 Å
- 6YKY chain A against the predicted model Q16659: TM-score 0.96, RMSD 1.36 Å
- 6YKY chain A against the predicted model Q16659: TM-score 0.96, RMSD 1.36 Å
Elsewhere
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