MolNFT v1 · #173146 · protein
Crystal structure of human mitogen activated protein kinase 6 (MAPK6)
7AQB · Mitogen-activated protein kinase 6: “Crystal structure of human mitogen activated protein kinase 6 (MAPK6)”. X-ray diffraction, 1 ligand (MG), 4 pockets (best druggability 0.78). MolNFT v1 #173146 on GenesisL1: 3D structure, binding…
- PDB
- 7AQB
- Type
- protein
- Length
- 568 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 6
- EC
- 2.7.11.24
- UniProt
- Q16659
- Ligands
- MG
- Pockets
- 4 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 6 (EC 2.7.11.24) | protein | 294 | 40% helix, 18% strand | Q16659 |
| B | Mitogen-activated protein kinase 6 (EC 2.7.11.24) | protein | 274 | 44% helix, 14% strand | Q16659 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 969 | 0.78 | 0.80 | 87 | empty |
| 2 | 465 | 0.66 | 0.78 | 62 | empty |
| 3 | 103 | 0.39 | 0.76 | 19 | empty |
| 4 | 72 | 0.38 | 0.78 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 752 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7AQB · Crystal structure of human mitogen activated protein kinase 6 (MAPK6) · the same entry in another collection · chain A against A, TM-score 1.00
- Q16659 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 6 (Q16659) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16659
- Elsewhere: RCSB PDB 7AQB · PDBe 7AQB · UniProt Q16659
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.