MolNFT v1 · #170867 · protein
Biochemical, cellular and structural characterization of novel ERK3 inhibitors
6YLC: “Biochemical, cellular and structural characterization of novel ERK3 inhibitors”. X-ray diffraction, 1 ligand (OXW). MolNFT v1 #170867 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6YLC
- Type
- protein
- Length
- 1,157 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q16659
- Ligands
- OXW
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 282 | — | Q16659 |
| B | — | protein | 292 | — | Q16659 |
| C | — | protein | 280 | — | Q16659 |
| D | — | protein | 303 | — | Q16659 |
Ligands and binding sites
- OXW · 5-fluoranyl-2-[5-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]benzenecarbonitrile · ligand · 4 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6YLC · Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors · the same entry in another collection · chain D against D, TM-score 1.00
- Q16659 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 6 (Q16659) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16659
- Elsewhere: RCSB PDB 6YLC · PDBe 6YLC · UniProt Q16659
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