UniProt Q15910
Histone-lysine N-methyltransferase EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (UniProt Q15910), EC 2.1.1.356, 2.1.1.43: 57 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 222 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q15910
- Protein
- Histone-lysine N-methyltransferase EZH2
- EC
- 2.1.1.356, 2.1.1.43
- Experimental structures
- 57
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 222 · 21 records with a druggable one
Structures
58 records of Q15910 in the MolNFT archive: 57 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4MI0 | Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2) | x-ray diffraction | A | — | — |
| 4MI0 | Human enhancer of zeste (drosophila) homolog 2(EZH2) | x-ray diffraction | A | — | — |
| 4MI5 | Crystal structure of the EZH2 SET domain | x-ray diffraction | A | — | — |
| 4MI5 | Crystal structure of the EZH2 set domain | x-ray diffraction | A | — | — |
| 5GSA | EED in complex with an allosteric PRC2 inhibitor | x-ray diffraction | C, D | — | — |
| 5GSA | Eed in complex with an allosteric PRC2 inhibitor | x-ray diffraction | C, D | — | — |
| 5H14 | EED in complex with an allosteric PRC2 inhibitor EED666 | x-ray diffraction | C, D | — | — |
| 5H14 | Eed in complex with an allosteric PRC2 inhibitor EED666 | x-ray diffraction | C, D | — | — |
| 5H15 | EED in complex with PRC2 allosteric inhibitor EED709 | x-ray diffraction | C, D | — | 5 (best 0.86) |
| 5H15 | Eed in complex with PRC2 allosteric inhibitor EED709 | x-ray diffraction | C, D | — | — |
| 5H17 | EED in complex with PRC2 allosteric inhibitor EED210 | x-ray diffraction | B | — | — |
| 5H17 | Eed in complex with PRC2 allosteric inhibitor EED210 | x-ray diffraction | B | — | — |
| 5H19 | EED in complex with PRC2 allosteric inhibitor EED162 | x-ray diffraction | B | — | — |
| 5H19 | Eed in complex with PRC2 allosteric inhibitor EED162 | x-ray diffraction | B | — | — |
| 5H24 | EED in complex with PRC2 allosteric inhibitor compound 8 | x-ray diffraction | C, D | — | — |
| 5H24 | Eed in complex with PRC2 allosteric inhibitor compound 8 | x-ray diffraction | C, D | — | — |
| 5H25 | EED in complex with PRC2 allosteric inhibitor compound 11 | x-ray diffraction | C, D | — | — |
| 5H25 | Eed in complex with PRC2 allosteric inhibitor compound 11 | x-ray diffraction | C, D | — | — |
| 5HYN | Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide | x-ray diffraction | A, F, K, Q | ZN, SAH | 20 (best 0.87) |
| 5HYN | Structure of human polycomb repressive complex 2 (PRC2) with oncogenic histone H3K27M peptide | x-ray diffraction | A, F, K, Q | — | — |
| 5IJ7 | Structure of Hs/AcPRC2 in complex with a pyridone inhibitor | x-ray diffraction | A, B | 6BN, ZN | — |
| 5IJ7 | Structure of HS/ACPRC2 in complex with a pyridone inhibitor | x-ray diffraction | A, B | — | — |
| 5IJ8 | Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor | x-ray diffraction | A, B | 6BN, ZN | 18 (best 0.87) |
| 5IJ8 | Structure of the primary oncogenic mutant Y641N HS/ACPRC2 in complex with a pyridone inhibitor | x-ray diffraction | A, B | — | — |
| 5LS6 | Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor | x-ray diffraction | A, D, G, J | ZN, 74D | 20 (best 0.87) |
| 5LS6 | Structure of human polycomb repressive complex 2 (PRC2) with inhibitor | x-ray diffraction | A, D, G, J | ZN, 74D | — |
| 5U5T | Crystal structure of EED in complex with H3K27Me3 peptide and… | x-ray diffraction | C, D | — | 4 (best 0.86) |
| 5U5T | Crystal structure of eed in complex with H3K27ME3 peptide and 3… | x-ray diffraction | C, D | — | — |
| 5U62 | Crystal structure of EED in complex with H3K27Me3 peptide and… | x-ray diffraction | C, D | — | 5 (best 0.86) |
| 5U62 | Crystal structure of eed in complex with H3K27ME3 peptide and 6… | x-ray diffraction | C, D | — | — |
| 5WG6 | Human Polycomb Repressive Complex 2 in complex with GSK126 inhibitor | x-ray diffraction | A, C | ZN, A9G | 20 (best 0.86) |
| 5WG6 | Human polycomb repressive complex 2 in complex with GSK126 inhibitor | x-ray diffraction | A, C | ZN, A9G | — |
| 5WUK | Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound | x-ray diffraction | B | — | 3 (best 0.86) |
| 5WUK | Crystal structure of eed [G255D] in complex with EZH2 peptide and EED226 compound | x-ray diffraction | B | — | — |
| 6C23 | Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Compact Active State | electron microscopy | K, C | — | — |
| 6C23 | Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the compact active state | electron microscopy | K, C | — | — |
| 6C24 | Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State | electron microscopy | K, C | — | 14 (best 0.86) |
| 6C24 | Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the extended active state | electron microscopy | K, C | — | — |
| 6LO2 | Crystal structure of EED in complex with EZH2 peptide and compound 11# | x-ray diffraction | C, D | — | 5 (best 0.87) |
| 6LO2 | Crystal structure of eed in complex with EZH2 peptide and compound 11# | x-ray diffraction | C, D | — | — |
| 6U4Y | Crystal Structure of an EZH2-EED Complex in an Oligomeric State | x-ray diffraction | A, B, C | — | 17 (best 0.87) |
| 6U4Y | Crystal structure of an EZH2-eed complex in an oligomeric state | x-ray diffraction | A, B, C | — | — |
| 6WKR | PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome | electron microscopy | C | SAH | 10 (best 0.86) |
| 6WKR | PRC2-AEBP2-JARID2 bound to H2AK119UB1 nucleosome | electron microscopy | C | — | — |
| 7AT8 | Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2. | electron microscopy | — | — | |
| 7QJG | EED in complex with PRC2 allosteric inhibitor compound 6 | x-ray diffraction | C, D | — | 6 (best 0.86) |
| 7QJG | Eed in complex with PRC2 allosteric inhibitor compound 6 | x-ray diffraction | C, D | — | — |
| 7QJU | EED in complex with PRC2 allosteric inhibitor compound 7 | x-ray diffraction | C, D | — | 7 (best 0.87) |
| 7QJU | Eed in complex with PRC2 allosteric inhibitor compound 7 | x-ray diffraction | C, D | — | — |
| 7QK4 | EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683) | x-ray diffraction | B | — | 3 (best 0.87) |
| 7QK4 | Eed in complex with PRC2 allosteric inhibitor compound 22 (MAK683) | x-ray diffraction | B | — | — |
| 8EQV | Cryo-EM structure of PRC2 in complex with the long isoform of AEBP2 | electron microscopy | D | — | 12 (best 0.86) |
| 8FYH | G4 RNA-mediated PRC2 dimer | electron microscopy | A, G | ZN | 11 (best 0.86) |
| 8T9G | Automethylated PRC2 dimer bound to nucleosome | electron microscopy | C, I | SAH | 13 (best 0.87) |
| 8TAS | PRC2 monomer bound to nucleosome | electron microscopy | E | SAH | 11 (best 0.88) |
| 8TB9 | PRC2-J119-450 monomer bound to H1-nucleosome | electron microscopy | E | SAH | 8 (best 0.86) |
| 9C8U | Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min | electron microscopy | A | ZN | 10 (best 0.86) |
| Q15910 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase EZH2 (Q15910) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 9 records
- SAH · S-adenosyl-L-homocysteine · in 5 records
- 6BN · 5,8-dichloro-2-[(4-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)-3,4-dihydroisoquinolin-1(2H)-one · in 2 records
- 74D · 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide · in 2 records
- A9G · 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide · in 2 records
Experiment against prediction
- 5IJ8 chain B against the predicted model Q15910: TM-score 0.95, RMSD 2.15 Å
- 5IJ8 chain B against the predicted model Q15910: TM-score 0.95, RMSD 2.15 Å
- 5IJ7 chain B against the predicted model Q15910: TM-score 0.95, RMSD 2.18 Å
- 5IJ7 chain B against the predicted model Q15910: TM-score 0.95, RMSD 2.18 Å
- 6C24 chain K against the predicted model Q15910: TM-score 0.94, RMSD 1.61 Å
- 6C24 chain K against the predicted model Q15910: TM-score 0.94, RMSD 1.61 Å
- 6C23 chain K against the predicted model Q15910: TM-score 0.94, RMSD 1.83 Å
- 6C23 chain K against the predicted model Q15910: TM-score 0.94, RMSD 1.83 Å
- 5IJ7 chain A against the predicted model Q15910: TM-score 0.93, RMSD 2.73 Å
- 5IJ7 chain A against the predicted model Q15910: TM-score 0.93, RMSD 2.73 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.