MolNFT v1 · #165735 · protein
Crystal structure of an EZH2-eed complex in an oligomeric state
6U4Y · Histone-lysine N-methyltransferase EZH2: “Crystal structure of an EZH2-eed complex in an oligomeric state”. X-ray diffraction, 20 pockets (best druggability 0.87). MolNFT v1 #165735 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6U4Y
- Type
- protein
- Length
- 1,562 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-lysine N-methyltransferase EZH2; Polycomb protein eed
- EC
- 2.1.1.43
- UniProt
- Q15910, O75530
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 6 distinct chains · 21% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) | protein | 160 | 56% helix, 8% strand | Q15910 |
| B | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) | protein | 166 | 55% helix, 11% strand | Q15910 |
| C | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) | protein | 157 | 55% helix, 8% strand | Q15910 |
| D | Polycomb protein eed | protein | 361 | 6% helix, 47% strand | O75530 |
| E | Polycomb protein eed | protein | 360 | 6% helix, 48% strand | O75530 |
| F | Polycomb protein eed | protein | 358 | 6% helix, 48% strand | O75530 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 419 | 0.87 | 0.95 | 41 | empty |
| 2 | 413 | 0.86 | 0.95 | 42 | empty |
| 3 | 417 | 0.86 | 0.94 | 41 | empty |
| 4 | 447 | 0.63 | 0.77 | 64 | empty |
| 5 | 330 | 0.59 | 0.77 | 59 | empty |
Interfaces
12 interfaces between chains.
- A–D · 3044 Ų buried · 37 hydrogen bonds · protein-protein
- B–E · 3013 Ų buried · 32 hydrogen bonds · protein-protein
- C–F · 3007 Ų buried · 34 hydrogen bonds · protein-protein
- B–C · 881 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 880 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6U4Y · Crystal Structure of an EZH2-EED Complex in an Oligomeric State · the same entry in another collection · chain F against F, TM-score 1.00
- O75530 · AlphaFold monomer V2.0 prediction for polycomb protein eed (O75530) · a predicted model of the same protein · chain F against A, TM-score 0.99
- Q15910 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase EZH2 (Q15910) · a predicted model of the same protein · chain C against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15910
- Every structure of UniProt O75530
- Elsewhere: RCSB PDB 6U4Y · PDBe 6U4Y · UniProt Q15910 · UniProt O75530
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