MolNFT v1 · #138796 · protein
Crystal structure of eed [G255D] in complex with EZH2 peptide and EED226 compound
5WUK: “Crystal structure of eed [G255D] in complex with EZH2 peptide and EED226 compound”. X-ray diffraction, 1 ligand (73K). MolNFT v1 #138796 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WUK
- Type
- protein
- Length
- 394 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O75530, Q15910
- Ligands
- 73K
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 366 | — | O75530 |
| B | — | protein | 28 | — | Q15910 |
Ligands and binding sites
- 73K · N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine · ligand · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5WUK · Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound · the same entry in another collection · chain A against A, TM-score 1.00
- O75530 · AlphaFold monomer V2.0 prediction for polycomb protein eed (O75530) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q15910 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase EZH2 (Q15910) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75530
- Every structure of UniProt Q15910
- Elsewhere: RCSB PDB 5WUK · PDBe 5WUK · UniProt O75530 · UniProt Q15910
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