UniProt Q15904
V-type proton ATPase subunit S1 (Q15904)
V-type proton ATPase subunit S1 (UniProt Q15904): 7 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15904
- Protein
- V-type proton ATPase subunit S1
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 11 · 2 records with a druggable one
Structures
8 records of Q15904 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6WLW | The Vo region of human V-ATPase in state 1 (focused refinement) | electron microscopy | U | NAG, WSS, PTY, CLR | 6 (best 0.83) |
| 6WLW | The vo region of human V-ATPase in state 1 (focused refinement) | electron microscopy | U | NAG, WSS, PTY, CLR | — |
| 6WM2 | Human V-ATPase in state 1 with sidk and ADP | electron microscopy | U | NAG, WSS, CLR, PTY | — |
| 6WM3 | Human V-ATPase in state 2 with sidk and ADP | electron microscopy | U | NAG | — |
| 6WM4 | Human V-ATPase in state 3 with SidK and ADP | electron microscopy | U | NAG | 1 (best 0.82) |
| 6WM4 | Human V-ATPase in state 3 with sidk and ADP | electron microscopy | U | NAG | — |
| 7UNF | CryoEM structure of a mEAK7 bound human V-ATPase complex | electron microscopy | s | NAG, POV | — |
| Q15904 | AlphaFold monomer V2.0 prediction for V-type proton ATPase subunit S1 (Q15904) | predicted | A | — | 4 (best 0.39) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 7 records
- CLR · Cholesterol · in 3 records
- PTY · Phosphatidylethanolamine · in 3 records
- WSS · tri(methyl)-[2-[[(2~{R})-2-[(~{Z})-octadec-9-enoyl]oxy-3-[(~{E})-1-oxidanylideneoctadec-9-enoxy]propoxy]-oxidanyl-phosphoryl]oxyethyl]azanium · in 3 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 1 record
Experiment against prediction
- 7UNF chain s against the predicted model Q15904: TM-score 0.81, RMSD 2.01 Å
- 6WLW chain U against the predicted model Q15904: TM-score 0.81, RMSD 1.86 Å
- 6WLW chain U against the predicted model Q15904: TM-score 0.81, RMSD 1.86 Å
- 6WM2 chain U against the predicted model Q15904: TM-score 0.81, RMSD 1.88 Å
- 6WM4 chain U against the predicted model Q15904: TM-score 0.81, RMSD 1.94 Å
- 6WM4 chain U against the predicted model Q15904: TM-score 0.81, RMSD 1.94 Å
- 6WM3 chain U against the predicted model Q15904: TM-score 0.80, RMSD 2.18 Å
Elsewhere
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