UniProt Q15878
Voltage-dependent R-type calcium channel subunit alpha-1E (Q15878)
Voltage-dependent R-type calcium channel subunit alpha-1E (UniProt Q15878): 4 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 45 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q15878
- Protein
- Voltage-dependent R-type calcium channel subunit alpha-1E
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 45 · 3 records with a druggable one
Structures
5 records of Q15878 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7XLQ | Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the… | electron microscopy | A | Y01, R16, 3PE, CA | 17 (best 0.86) |
| 7YG5 | Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the… | electron microscopy | A | Y01, R16, 3PE, CA, TOR | — |
| 8EPL | Human R-type voltage-gated calcium channel Cav2.3 at 3.1 Angstrom resolution | electron microscopy | A | CA, CLR, 3PE, PT5 | 15 (best 0.84) |
| 8EPM | Human R-type voltage-gated calcium channel Cav2.3 CH2II-deleted mutant at 3.1 Angstrom resolution | electron microscopy | A | CA | 13 (best 0.85) |
| Q15878 | AlphaFold monomer V2.0 prediction for voltage-dependent R-type calcium channel subunit alpha-1E… | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 4 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 3 records
- R16 · Hexadecane · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- CLR · Cholesterol · in 1 record
- PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · in 1 record
- TOR · [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate · in 1 record
Experiment against prediction
- 8EPM chain A against the predicted model Q15878: TM-score 0.97, RMSD 1.97 Å
- 7XLQ chain A against the predicted model Q15878: TM-score 0.95, RMSD 2.50 Å
- 7YG5 chain A against the predicted model Q15878: TM-score 0.95, RMSD 2.51 Å
- 8EPL chain A against the predicted model Q15878: TM-score 0.94, RMSD 2.42 Å
Elsewhere
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