UniProt Q15661
Tryptase alpha/beta-1 (Q15661)
Tryptase alpha/beta-1 (UniProt Q15661), EC 3.4.21.59: 24 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 72 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15661
- Protein
- Tryptase alpha/beta-1
- EC
- 3.4.21.59
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 72 · 7 records with a druggable one
Structures
25 records of Q15661 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4A6L | beta-tryptase inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4A6L | Beta-tryptase inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4MPU | Human beta-tryptase co-crystal structure with (6S,8R)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidi… | x-ray diffraction | A, B | — | — |
| 4MPU | Human beta-tryptase co-crystal structure with (6S,8R)-N,N'-BIS[3-({4… | x-ray diffraction | A, B | — | — |
| 4MPV | Human beta-tryptase co-crystal structure with (2R,4S)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidi… | x-ray diffraction | A, B | — | — |
| 4MPV | Human beta-tryptase co-crystal structure with (2R,4S)-N,N'-BIS[3-({4… | x-ray diffraction | A, B | — | — |
| 4MPW | Human beta-tryptase co-crystal structure with [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzofur… | x-ray diffraction | A, B | — | — |
| 4MPW | Human beta-tryptase co-crystal structure with [(1,1,3,3… | x-ray diffraction | A, B | — | — |
| 4MPX | Human beta-tryptase co-crystal structure with [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzothi… | x-ray diffraction | A, B | — | — |
| 4MPX | Human beta-tryptase co-crystal structure with [(1,1,3,3… | x-ray diffraction | A, B | — | — |
| 4MQA | Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methyl… | x-ray diffraction | A, B | — | — |
| 4MQA | Human beta-tryptase co-crystal structure with {(1,1,3,3… | x-ray diffraction | A, B | — | — |
| 5WI6 | Human beta-1 tryptase mutant Ile99Cys | x-ray diffraction | A, B, C, D | SO4, 0GJ | 12 (best 0.54) |
| 5WI6 | Human beta-1 tryptase mutant ILE99CYS | x-ray diffraction | A, B, C, D | SO4 | — |
| 6O1F | Complex between soybean trypsin inhibitor beta1-tryptase and a humanized fab | x-ray diffraction | A | — | 4 (best 0.76) |
| 6O1F | Complex between soybean trypsin inhibitor BETA1-tryptase and a humanized Fab | x-ray diffraction | A | — | — |
| 6P0P | Human beta-tryptase co-crystal structure with 5-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-2-(… | x-ray diffraction | A, B | Y35, SO4 | 4 (best 0.49) |
| 6P0P | Human beta-tryptase co-crystal structure with 5-{4-[3-(aminomethyl)… | x-ray diffraction | A, B | Y35, SO4 | — |
| 6VVU | Anti-Tryptase fab E104.v1 bound to tryptase | x-ray diffraction | A, B, D, C | CA, 0GJ | 9 (best 0.70) |
| 6VVU | Anti-tryptase Fab E104.V1 bound to tryptase | x-ray diffraction | A, B, D, C | CA | — |
| 8VGH | CryoEM structure of tryptase in complex with wild type anti-tryptase Fab E104.v1 | electron microscopy | A, B, C, D | — | 8 (best 0.69) |
| 8VGI | CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab… | electron microscopy | A, B, C, D | — | 12 (best 0.71) |
| 8VGJ | CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab… | electron microscopy | A, B, C, D | — | 10 (best 0.73) |
| 8VGK | CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab… | electron microscopy | A, B, C, D | — | 10 (best 0.74) |
| Q15661 | AlphaFold monomer V2.0 prediction for tryptase ALPHA/BETA-1 (Q15661) | predicted | A | — | 3 (best 0.33) |
Ligands
- SO4 · Sulfate ion · in 4 records
- 0GJ · L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide · in 2 records
- CA · Calcium ion · in 2 records
- Y35 · (3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}[1, 1'-biphenyl]-3-yl){4-[3-(aminomethyl)phenyl]piperidin-1-yl}[3,4-di(hydroxy-kappao)phenyl]methanonato(2-) hydroxyborate(1-) · in 2 records
Experiment against prediction
- 4MPX chain A against the predicted model Q15661: TM-score 1.00, RMSD 0.23 Å
- 4MPX chain A against the predicted model Q15661: TM-score 1.00, RMSD 0.23 Å
- 4MPU chain A against the predicted model Q15661: TM-score 1.00, RMSD 0.25 Å
- 4MPU chain A against the predicted model Q15661: TM-score 1.00, RMSD 0.25 Å
- 4A6L chain A against the predicted model Q15661: TM-score 1.00, RMSD 0.26 Å
- 4A6L chain A against the predicted model Q15661: TM-score 1.00, RMSD 0.26 Å
- 4MPV chain A against the predicted model Q15661: TM-score 1.00, RMSD 0.26 Å
- 4MPV chain A against the predicted model Q15661: TM-score 1.00, RMSD 0.26 Å
- 6P0P chain A against the predicted model Q15661: TM-score 1.00, RMSD 0.26 Å
- 6P0P chain A against the predicted model Q15661: TM-score 1.00, RMSD 0.26 Å
Elsewhere
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