Human beta-tryptase co-crystal structure with 5-{4-[3-(aminomethyl) PHENYL]PIPERIDINE-1-carbonyl}-2-(3'-{4-[3-(aminomethyl) PHENYL]PIPERIDINE-1-carbonyl}-[1,1'-biphenyl]-3-yl)-2-hydroxy-2H-1,3, 2-benzodioxaborol-2-uide

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• Y35 · (3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}[1, 1'-biphenyl]-3-yl){4-[3-(aminomethyl)phenyl]piperidin-1-yl}[3,4-di(hydroxy-kappao)phenyl]methanonato(2-) hydroxyborate(1-) · ligand · chains A, B
• SO4 · Sulfate ion · ion · 3 copies · chains A, B
• PGE · Triethylene glycol · additive · 2 copies · chains A, B
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6P0P · Human beta-tryptase co-crystal structure with 5-{4-[3-(aminomethyl)phenyl]piperidine-1-car… · the same entry in another collection · chain A against A, TM-score 1.00
• Q15661 · AlphaFold monomer V2.0 prediction for tryptase ALPHA/BETA-1 (Q15661) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q15661
• Elsewhere: RCSB PDB 6P0P · PDBe 6P0P · UniProt Q15661