UniProt Q13976
cGMP-dependent protein kinase 1 (Q13976)
cGMP-dependent protein kinase 1 (UniProt Q13976), EC 2.7.11.12: 34 experimental structures on GenesisL1, 14 ligands bound, 25 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q13976
- Protein
- cGMP-dependent protein kinase 1
- EC
- 2.7.11.12
- Experimental structures
- 34
- Predicted models
- 0
- Ligands
- 14
- Pockets
- 25 · 5 records with a druggable one
Structures
34 records of Q13976 in the MolNFT archive: 34 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZXA | Solution Structure of the Coiled-Coil Domain of cGMP-dependent Protein Kinase Ia | solution nmr | A, B | — | — |
| 1ZXA | Solution structure of the coiled-coil domain of cgmp-dependent protein kinase ia | solution nmr | A, B | — | — |
| 4KU7 | Structures of PKGI Reveal a cGMP-Selective Activation Mechanism | x-ray diffraction | A | — | — |
| 4KU7 | Structures of pkgi reveal a cgmp-selective activation mechanism | x-ray diffraction | A | — | — |
| 4KU8 | Structures of PKGI Reveal a cGMP-Selective Activation Mechanism | x-ray diffraction | A, B, C | — | — |
| 4KU8 | Structures of pkgi reveal a cgmp-selective activation mechanism | x-ray diffraction | A, B, C | — | — |
| 4QX5 | Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: Insights for PKG… | x-ray diffraction | A | — | — |
| 4QX5 | Neutron diffraction reveals hydrogen bonds critical for cgmp-selective activation: insights for pkg… | x-ray diffraction | A | — | — |
| 4QXK | Joint X-ray/neutron structure of PKGIbeta in complex with cGMP | x-ray diffraction, neutron diffraction | A | — | — |
| 4QXK | Joint X-RAY/NEUTRON structure of pkgibeta in complex with cgmp | x-ray diffraction; neutron diffraction | A | — | — |
| 4R4L | Crystal structure of wt cGMP dependent protein kinase I alpha (PKGI alpha) leucine zipper | x-ray diffraction | A, B, C | — | — |
| 4R4L | Crystal structure of wt cgmp dependent protein kinase I alpha (pkgi alpha) leucine zipper | x-ray diffraction | A, B, C | — | — |
| 4R4M | Crystal structure of C42L cGMP dependent protein kinase I alpha (PKGI alpha) leucine zipper | x-ray diffraction | A, B, C | — | — |
| 4R4M | Crystal structure of C42L cgmp dependent protein kinase I alpha (pkgi alpha) leucine zipper | x-ray diffraction | A, B, C | — | — |
| 4Z07 | Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP | x-ray diffraction | A, C, E | — | — |
| 4Z07 | Co-crystal structure of the tandem cnb (cnb-A/B) domains of human pkg I beta with cgmp | x-ray diffraction | A, C, E | — | — |
| 5J48 | Pkg I'S carboyl terminal cyclic nucleotide binding domain (cnb-B) in a complex with 8-pcpt-cgmp | x-ray diffraction | A, B | — | — |
| 5JAX | PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP | x-ray diffraction | A | 6J7, CA, NA | 1 (best 0.62) |
| 5JAX | Pkg I'S carboyl terminal cyclic nucleotide binding domain (cnb-B) in a complex with 8-br-cgmp | x-ray diffraction | A | — | — |
| 5JD7 | PKG I's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with PET-cGMP | x-ray diffraction | A | 6JR | 1 (best 0.63) |
| 5JD7 | Pkg I'S carboxyl terminal cyclic nucleotide binding domain (cnb-B) in a complex with pet-cgmp | x-ray diffraction | A | — | — |
| 5L0N | PKG I's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with RP-cGMP | x-ray diffraction | A | SO4, CA, 6ZA | — |
| 5L0N | Pkg I'S carboxyl terminal cyclic nucleotide binding domain (cnb-B) in a complex with rp-cgmp | x-ray diffraction | A | SO4, CA, 6ZA | — |
| 6BDL | Crystal structure of cGMP-dependent protein kinase Ialpha (PKG Ialpha) catalytic domain in apo state | x-ray diffraction | A, B | — | 5 (best 0.66) |
| 6BDL | Crystal structure of cgmp-dependent protein kinase ialpha (pkg ialpha) catalytic domain in apo state | x-ray diffraction | A, B | — | — |
| 6BG2 | Crystal structure of cGMP-dependent protein kinase Ialpha (PKG Ialpha) catalytic domain in AMP-PNP… | x-ray diffraction | C, B, A, D | ANP, MN | — |
| 6BG2 | Crystal structure of cgmp-dependent protein kinase ialpha (pkg ialpha) catalytic domain in AMP-pnp… | x-ray diffraction | C, B, A, D | ANP, MN | — |
| 6C0T | Crystal structure of cgmp-dependent protein kinase ialpha (pkg ialpha) catalytic domain bound with… | x-ray diffraction | A | EE4 | — |
| 7LV3 | Crystal structure of human protein kinase G (pkg) R-C complex in inhibited state | x-ray diffraction | A, B | MN, ANP | — |
| 7MBJ | Crystal structure of cgmp dependent protein kinase I alpha (pkg I ALPHA)CNB-a domain with R177Q… | x-ray diffraction | A, B | — | — |
| 7SSB | Co-structure of PKG1 regulatory domain with compound 33 | x-ray diffraction | A | B4I | — |
| 7T4T | Crystal Structure of cGMP-dependent Protein Kinase | x-ray diffraction | A, B | PCG, ATP, CL | 7 (best 0.83) |
| 7T4W | Crystal Structure of cGMP-dependent Protein Kinase | x-ray diffraction | A, B | EZJ, CL | 11 (best 0.74) |
| Q13976 | AlphaFold monomer V2.0 prediction for cgmp-dependent protein kinase 1 (Q13976) | — | — | — |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 3 records
- CA · Calcium ion · in 3 records
- MN · Manganese (II) ion · in 3 records
- 6ZA · 2-amino-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidenetetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one · in 2 records
- CL · Chloride ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- 6J7 · 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one · in 1 record
- 6JR · 3-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-phenyl-3,4-dihydro-9H-imidazo[1,2-a]purin-9-one · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- B4I · 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-nitrobenzoic acid · in 1 record
- EE4 · N-[(3R,4R)-4-{[4-(2-fluoro-3-methoxy-6-propoxybenzene-1-carbonyl)benzene-1-carbonyl]amino}pyrrolidin-3-yl]-1H-indazole-5-carboxamide · in 1 record
- EZJ · (2R)-2-({(2S,3S)-1-[(1H-benzimidazol-2-yl)methyl]-2-phenylpiperidin-3-yl}oxy)-2-(3,5-dichlorophenyl)ethan-1-ol · in 1 record
- NA · Sodium ion · in 1 record
- PCG · Cyclic guanosine monophosphate · in 1 record
Elsewhere
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