UniProt Q13546
Receptor-interacting serine/threonine-protein kinase 1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (UniProt Q13546), EC 2.7.11.1: 38 experimental structures on GenesisL1, 18 ligands bound, 69 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q13546
- Protein
- Receptor-interacting serine/threonine-protein kinase 1
- EC
- 2.7.11.1
- Experimental structures
- 38
- Predicted models
- 0
- Ligands
- 18
- Pockets
- 69 · 9 records with a druggable one
Structures
38 records of Q13546 in the MolNFT archive: 38 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4ITH | Crystal structure of RIP1 kinase in complex with necrostatin-1 analog | x-ray diffraction | A, B | — | — |
| 4ITH | Crystal structure of RIP1 kinase in complex with necrostatin-1 analog | x-ray diffraction | A, B | — | — |
| 4ITI | Crystal structure of RIP1 kinase in complex with necrostatin-3 analog | x-ray diffraction | A, B | — | — |
| 4ITI | Crystal structure of RIP1 kinase in complex with necrostatin-3 analog | x-ray diffraction | A, B | — | — |
| 4ITJ | Crystal structure of RIP1 kinase in complex with necrostatin-4 | x-ray diffraction | A, B | — | — |
| 4ITJ | Crystal structure of RIP1 kinase in complex with necrostatin-4 | x-ray diffraction | A, B | — | — |
| 4NEU | X-ray structure of Receptor Interacting Protein 1 (RIP1)kinase domain with a 1-aminoisoquinoline… | x-ray diffraction | A, B | — | — |
| 4NEU | X-ray structure of receptor interacting protein 1 (RIP1)KINASE domain with a 1-aminoisoquinoline… | x-ray diffraction | A, B | — | — |
| 5HX6 | Crystal structure of RIP1 kinase with a benzo[b][1,4]oxazepin-4-one | x-ray diffraction | A, B | 65U | 7 (best 0.75) |
| 5HX6 | Crystal structure of RIP1 kinase with a BENZO[B][1,4]OXAZEPIN-4-one | x-ray diffraction | A, B | — | — |
| 5TX5 | Rip1 Kinase ( flag 1-294, C34A, C127A, C233A, C240A) with GSK772 | x-ray diffraction | A, B | 7MJ | — |
| 5TX5 | RIP1 kinase ( flag 1-294, C34A, C127A, C233A, C240A) with GSK772 | x-ray diffraction | A, B | 7MJ | — |
| 5ZMZ | Amyloid core of RIP1 | x-ray diffraction | A | — | — |
| 5ZMZ | Amyloid core of RIP1 | x-ray diffraction | A | — | — |
| 6AC5 | Crystal structure of RIPK1 death domain GlcNAcylated by EPEC effector NleB | x-ray diffraction | A | NAG, SO4 | — |
| 6AC5 | Crystal structure of RIPK1 death domain glcnacylated by epec effector nleb | x-ray diffraction | A | NAG, SO4 | — |
| 6C3E | Crystal structure of RIP1 kinase bound to inhibitor | x-ray diffraction | A, B | EJY | 7 (best 0.80) |
| 6C3E | Crystal structure of RIP1 kinase bound to inhibitor | x-ray diffraction | A, B | EJY | — |
| 6C4D | Structure based design of RIP1 kinase inhibitors | x-ray diffraction | A, B, C, D | EJP | 16 (best 0.76) |
| 6C4D | Structure based design of RIP1 kinase inhibitors | x-ray diffraction | A, B, C, D | EJP | — |
| 6HHO | Crystal structure of RIP1 kinase in complex with GSK547 | x-ray diffraction | A, B | G4W | — |
| 6HHO | Crystal structure of RIP1 kinase in complex with GSK547 | x-ray diffraction | A, B | G4W | — |
| 6NW2 | Structure of human RIPK1 kinase domain in complex with compound 11 | x-ray diffraction | A, B | L4Y | — |
| 6NYH | Structure of human RIPK1 kinase domain in complex with GNE684 | x-ray diffraction | A, B | L8D, IOD | — |
| 6OCQ | Crystal structure of RIP1 kinase in complex with a pyrrolidine | x-ray diffraction | A, B | M5J, SO4 | 11 (best 0.80) |
| 6OCQ | Crystal structure of RIP1 kinase in complex with a pyrrolidine | x-ray diffraction | A, B | M5J, SO4 | — |
| 6R5F | Crystal structure of RIP1 kinase in complex with DHP77 | x-ray diffraction | A, B, C, D | JSW | — |
| 6RLN | Crystal structure of RIP1 kinase in complex with GSK3145095 | x-ray diffraction | A, B | K8K | 6 (best 0.76) |
| 6RLN | Crystal structure of RIP1 kinase in complex with GSK3145095 | x-ray diffraction | A, B | K8K | — |
| 7CJB | VHL recognizes hydroxyproline in RIPK1 | x-ray diffraction | D, H, L, P | — | — |
| 7CJB | Vhl recognizes hydroxyproline in RIPK1 | x-ray diffraction | D, H, L, P | — | — |
| 7FCZ | Crystal Structure of human RIPK1 kinase domain in complex with a novel inhibitor | x-ray diffraction | A, B | 3IF | 5 (best 0.78) |
| 7FCZ | Crystal structure of human RIPK1 kinase domain in complex with a novel inhibitor | x-ray diffraction | A, B | 3IF | — |
| 7FD0 | Crystal structure of human RIPK1 kinase domain in complex with a novel inhibitor | x-ray diffraction | A, B | 3IU | — |
| 7XMK | Crystal structure of human RIPK1 kinase domain in complex with compound SKLB923 | x-ray diffraction | A, B | IOD, GO4 | 6 (best 0.77) |
| 7YDX | Crystal structure of human RIPK1 kinase domain in complex with compound RI-962 | x-ray diffraction | A, B | 3CI, IOD | 6 (best 0.77) |
| 8I2N | The RIPK1 kinase domain in complex with QY7-2B compound | x-ray diffraction | A, B | O4U | 5 (best 0.76) |
| Q13546 | AlphaFold monomer V2.0 prediction for receptor-interacting SERINE/THREONINE-protein kinase 1… | — | — | — |
Ligands
- SO4 · Sulfate ion · in 4 records
- IOD · Iodide ion · in 3 records
- 3IF · N-[(3S)-7-(2-cyclopropylethynyl)-5-methyl-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4H-1,2,4-triazole-3-carboxamide · in 2 records
- 7MJ · 3-benzyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-5-carboxamide · in 2 records
- EJP · (3S)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile · in 2 records
- EJY · 2-benzyl-5-nitro-1H-benzimidazole · in 2 records
- G4W · 6-[4-[(5~{S})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]carbonylpiperidin-1-yl]pyrimidine-4-carbonitrile · in 2 records
- K8K · ~{N}-[(3~{S})-7,9-bis(fluoranyl)-2-oxidanylidene-1,3,4, 5-tetrahydro-1-benzazepin-3-yl]-3-(phenylmethyl)-1~{H}-1,2,4-triazole-5-carboxamide · in 2 records
- M5J · 1-[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- 3CI · 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-phenylethyl]indole-3-carboxamide · in 1 record
- 3IU · N-[(3S)-5-methyl-7-[2-(oxan-4-yl)ethynyl]-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4H-1,2,4-triazole-3-carboxamide · in 1 record
- 65U · 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide · in 1 record
- GO4 · 5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide · in 1 record
- JSW · [(5~{S})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone · in 1 record
- L4Y · (5R)-5-methyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide · in 1 record
- L8D · (5S)-N-[(3S)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido[3,4-b]azepin-3-yl]-5-phenyl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide · in 1 record
- O4U · ~{N}-methyl-1-[4-[[[1-methyl-5-(phenylmethyl)pyrazol-3-yl]carbonylamino]methyl]phenyl]benzimidazole-5-carboxamide · in 1 record
Elsewhere
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