MolNFT v1 · #178345 · protein
Crystal structure of human RIPK1 kinase domain in complex with a novel inhibitor
7FD0: “Crystal structure of human RIPK1 kinase domain in complex with a novel inhibitor”. X-ray diffraction, 1 ligand (3IU). MolNFT v1 #178345 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7FD0
- Type
- protein
- Length
- 523 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q13546
- Ligands
- 3IU
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 266 | — | Q13546 |
| B | — | protein | 257 | — | Q13546 |
Ligands and binding sites
- 3IU · N-[(3S)-5-methyl-7-[2-(oxan-4-yl)ethynyl]-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4H-1,2,4-triazole-3-carboxamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7FD0 · Crystal Structure of human RIPK1 kinase domain in complex with a novel inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- Q13546 · AlphaFold monomer V2.0 prediction for receptor-interacting SERINE/THREONINE-protein… · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13546
- Elsewhere: RCSB PDB 7FD0 · PDBe 7FD0 · UniProt Q13546
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