UniProt Q13422
DNA-binding protein Ikaros (Q13422)
DNA-binding protein Ikaros (UniProt Q13422): 9 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13422
- Protein
- DNA-binding protein Ikaros
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 12 · 4 records with a druggable one
Structures
10 records of Q13422 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6H0F | Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2) | x-ray diffraction | C, F, I, L | Y70, ZN | — |
| 6H0F | Structure of DDB1-crbn-pomalidomide complex bound to IKZF1(ZF2) | x-ray diffraction | C, F, I, L | Y70, ZN | — |
| 8D7Z | Cereblon-DDB1 bound to CC-92480 and Ikaros ZF1-2-3 | electron microscopy | C | QFC, ZN | 2 (best 0.60) |
| 8D7Z | Cereblon-DDB1 bound to cc-92480 and ikaros ZF1-2-3 | electron microscopy | C | QFC, ZN | — |
| 8D80 | Cereblon~DDB1 bound to Iberdomide and Ikaros ZF1-2-3 | electron microscopy | C | 8W7, ZN | — |
| 8D80 | CEREBLON~DDB1 bound to iberdomide and ikaros ZF1-2-3 | electron microscopy | C | 8W7, ZN | — |
| 8RQC | Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2 | x-ray diffraction | B, E | QFC, ZN | 4 (best 0.73) |
| 8TNP | Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 | electron microscopy | C | Y70, ZN | 4 (best 0.80) |
| 8TNQ | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 | electron microscopy | C | MIQ, ZN | 2 (best 0.78) |
| Q13422 | AlphaFold monomer V2.0 prediction for DNA-binding protein ikaros (Q13422) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 9 records
- QFC · Mezigdomide · in 3 records
- Y70 · S-Pomalidomide · in 3 records
- 8W7 · (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione · in 2 records
- MIQ · 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione · in 1 record
Experiment against prediction
- 8RQC chain E against the predicted model Q13422: TM-score 0.85, RMSD 0.75 Å
- 6H0F chain C against the predicted model Q13422: TM-score 0.85, RMSD 1.62 Å
- 6H0F chain C against the predicted model Q13422: TM-score 0.85, RMSD 1.62 Å
- 8RQC chain B against the predicted model Q13422: TM-score 0.79, RMSD 0.63 Å
- 8D80 chain C against the predicted model Q13422: TM-score 0.65, RMSD 1.66 Å
- 8D80 chain C against the predicted model Q13422: TM-score 0.65, RMSD 1.66 Å
- 8D7Z chain C against the predicted model Q13422: TM-score 0.64, RMSD 0.90 Å
- 8D7Z chain C against the predicted model Q13422: TM-score 0.64, RMSD 0.90 Å
- 8TNP chain C against the predicted model Q13422: TM-score 0.61, RMSD 1.91 Å
- 8TNQ chain C against the predicted model Q13422: TM-score 0.58, RMSD 2.33 Å
Elsewhere
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