UniProt Q13093
Platelet-activating factor acetylhydrolase (Q13093)
Platelet-activating factor acetylhydrolase (UniProt Q13093), EC 3.1.1.47: 50 experimental structures on GenesisL1, 22 ligands bound, 2 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q13093
- Protein
- Platelet-activating factor acetylhydrolase
- EC
- 3.1.1.47
- Experimental structures
- 50
- Predicted models
- 0
- Ligands
- 22
- Pockets
- 2 · 1 record with a druggable one
Structures
50 records of Q13093 in the MolNFT archive: 50 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3D59 | Crystal structure of human plasma platelet activating factor acetylhydrolase | x-ray diffraction | A, B | — | — |
| 3D59 | Crystal structure of human plasma platelet activating factor acetylhydrolase | x-ray diffraction | A, B | — | — |
| 3D5E | Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited… | x-ray diffraction | A, B | — | — |
| 3D5E | Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited… | x-ray diffraction | A, B | — | — |
| 3F96 | Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited… | x-ray diffraction | A, B | — | — |
| 3F96 | Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited… | x-ray diffraction | A, B | — | — |
| 3F97 | Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited… | x-ray diffraction | A, B | — | — |
| 3F97 | Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited… | x-ray diffraction | A, B | — | — |
| 3F98 | Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited… | x-ray diffraction | A, B, C | — | — |
| 3F98 | Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited… | x-ray diffraction | A, B, C | — | — |
| 3F9C | Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited… | x-ray diffraction | A, B | — | — |
| 3F9C | Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited… | x-ray diffraction | A, B | — | — |
| 5I8P | Crystal structure of LP_PLA2 in complex with novel inhibitor | x-ray diffraction | A, B | VQ7 | — |
| 5I8P | Crystal structure of LP_PLA2 in complex with novel inhibitor | x-ray diffraction | A, B | — | — |
| 5I9I | Crystal structure of LP_PLA2 in complex with darapladib | x-ray diffraction | A, B | — | — |
| 5JAD | Compound binding to human lipoprotein-associated phospholipase A2 (lp- PLA2)DISCOVERED through… | x-ray diffraction | A | — | — |
| 5JAH | Exploitation of a novel binding pocket in human lipoprotein-associated phospholipase A2… | x-ray diffraction | A | — | — |
| 5JAL | Exploitation of a novel binding pocket in human lipoprotein-associated phospholipase A2… | x-ray diffraction | A | — | — |
| 5JAN | Exploitation of a novel binding pocket in human lipoprotein-associated phospholipase A2… | x-ray diffraction | A | — | — |
| 5JAO | Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2… | x-ray diffraction | A | CA, CL, 6HX | — |
| 5JAO | Exploitation of a novel binding pocket in human lipoprotein-associated phospholipase A2… | x-ray diffraction | A | — | — |
| 5JAP | Exploitation of a novel binding pocket in human lipoprotein-associated phospholipase A2… | x-ray diffraction | A | — | — |
| 5JAR | Exploitation of a novel binding pocket in human lipoprotein-associated phospholipase A2… | x-ray diffraction | A | — | — |
| 5JAS | Exploitation of a novel binding pocket in human lipoprotein-associated phospholipase A2… | x-ray diffraction | A | — | — |
| 5JAT | Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2… | x-ray diffraction | A | CL, 6HR | — |
| 5JAT | Exploitation of a novel binding pocket in human lipoprotein-associated phospholipase A2… | x-ray diffraction | A | — | — |
| 5JAU | Exploitation of a novel binding pocket in human lipoprotein-associated phospholipase A2… | x-ray diffraction | A | — | — |
| 5LP1 | Crystal structure of human lipoprotein-associated phospholipase A2 in complex with a… | x-ray diffraction | A | CL, 71H | 2 (best 0.57) |
| 5LP1 | Crystal structure of human lipoprotein-associated phospholipase A2 in complex with a… | x-ray diffraction | A | CL, 71H | — |
| 5LYY | Fragment-based inhibitors of lipoprotein associated phospholipase A2 | x-ray diffraction | A | 7BJ | — |
| 5LZ2 | Fragment-based inhibitors of Lipoprotein associated Phospholipase A2 | x-ray diffraction | A | NA, CL, 7BX | — |
| 5LZ2 | Fragment-based inhibitors of lipoprotein associated phospholipase A2 | x-ray diffraction | A | NA, CL, 7BX | — |
| 5LZ4 | Fragment-based inhibitors of Lipoprotein associated Phospholipase A2 | x-ray diffraction | A | CL, 7BW | — |
| 5LZ4 | Fragment-based inhibitors of lipoprotein associated phospholipase A2 | x-ray diffraction | A | CL, 7BW | — |
| 5LZ5 | Fragment-based inhibitors of lipoprotein associated phospholipase A2 | x-ray diffraction | A | CL, 7K4 | — |
| 5LZ7 | Fragment-based inhibitors of Lipoprotein associated Phospholipase A2 | x-ray diffraction | A | CL, 7BK | — |
| 5LZ7 | Fragment-based inhibitors of lipoprotein associated phospholipase A2 | x-ray diffraction | A | CL, 7BK | — |
| 5LZ8 | Fragment-based inhibitors of Lipoprotein associated Phospholipase A2 | x-ray diffraction | A | CL, 7BP | — |
| 5LZ8 | Fragment-based inhibitors of lipoprotein associated phospholipase A2 | x-ray diffraction | A | CL, 7BP | — |
| 5LZ9 | Fragment-based inhibitors of lipoprotein associated phospholipase A2 | x-ray diffraction | A | CL, NA, 7BR | — |
| 5YE7 | The crystal structure of lp-PLA2 in complex with a novel inhibitor | x-ray diffraction | B, A | 8U0, SO4 | — |
| 5YE8 | The crystal structure of lp-PLA2 in complex with a novel inhibitor | x-ray diffraction | B, A | 8U3 | — |
| 5YE9 | The crystal structure of lp-PLA2 in complex with a novel inhibitor | x-ray diffraction | A, B | 8U6, SO4 | — |
| 5YEA | The crystal structure of Lp-PLA2 in complex with a novel inhibitor | x-ray diffraction | A, B | SO4, 8U9 | — |
| 5YEA | The crystal structure of lp-PLA2 in complex with a novel inhibitor | x-ray diffraction | A, B | SO4, 8U9 | — |
| 6M06 | Crystal structure of lp-PLA2 in complex with a novel covalent inhibitor | x-ray diffraction | A, B | BWF | — |
| 6M07 | Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor | x-ray diffraction | A, B | BWO | — |
| 6M07 | Crystal structure of lp-PLA2 in complex with a novel covalent inhibitor | x-ray diffraction | A, B | BWO | — |
| 6M08 | Crystal structure of lp-PLA2 in complex with a novel covalent inhibitor. | x-ray diffraction | A, B | BWL | — |
| Q13093 | AlphaFold monomer V2.0 prediction for platelet-activating factor acetylhydrolase (Q13093) | — | — | — |
Ligands
- CL · Chloride ion · in 14 records
- SO4 · Sulfate ion · in 4 records
- NA · Sodium ion · in 3 records
- 71H · ~{N}-[2-(diethylamino)ethyl]-2-[2-[(4-fluorophenyl) methylsulfanyl]-4-oxidanylidene-5~{H}-cyclopenta[d]pyrimidin-1-yl]-~{N}-[[3-[4-(trifluoromethyl)phenyl]-1-bicyclo[1.1.1]pentanyl]methyl]ethanamide · in 2 records
- 7BK · 2-fluoranyl-5-[2-[(4~{R})-4-methyl-2-oxidanylidene-4-phenyl-pyrrolidin-1-yl]ethoxy]benzenecarbonitrile · in 2 records
- 7BP · 5-[2-[(4~{S})-4-~{tert}-butyl-2-oxidanylidene-pyrrolidin-1-yl]ethoxy]-2-fluoranyl-benzenecarbonitrile · in 2 records
- 7BW · 5-[2-(4,4-dimethyl-2-oxidanylidene-pyrrolidin-1-yl) ethoxy]-2-fluoranyl-benzenecarbonitrile · in 2 records
- 7BX · 3-cyano-~{N}-cyclopropyl-benzenesulfonamide · in 2 records
- 8U9 · 4-[[4-[4-chloranyl-3-(trifluoromethyl)phenoxy]-3-cyano-phenyl]sulfamoyl]benzoic acid · in 2 records
- BWO · (2S)-2-[(E)-3-[2-(diethylamino)ethyl-[[4-[4-(trifluoromethyl)-2-[2,2,2-tris(fluoranyl) ethoxy]phenyl]phenyl]methyl]amino]-1-oxidanyl-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid · in 2 records
- 6HR · 3-{2-[(2',6-dimethyl[1,1'-biphenyl]-3-yl)amino]-1,3-thiazol-4-yl}propan-1-ol · in 1 record
- 6HX · 2'-chloro-6-methyl[1,1'-biphenyl]-3-amine · in 1 record
- 7BJ · 3-[2-(4-fluoranylphenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione · in 1 record
- 7BR · 2-fluoranyl-5-[2-[(4~{S})-4-[4-methyl-1,1-bis(oxidanylidene)thian-4-yl]-2-oxidanylidene-pyrrolidin-1-yl]ethoxy]benzenecarbonitrile · in 1 record
- 7K4 · 2-fluoranyl-5-[2-[(4~{S})-4-methyl-2-oxidanylidene-4-phenyl-pyrrolidin-1-yl]ethoxy]benzenecarbonitrile · in 1 record
- 8U0 · N-[4-[(4-naphthalen-2-yloxyphenyl) sulfamoyl]phenyl]ethanamide · in 1 record
- 8U3 · N-[3,4-bis(fluoranyl)phenyl]methanesulfonamide · in 1 record
- 8U6 · N-[4-[(3-cyano-4-naphthalen-2-yloxy-phenyl) sulfamoyl]phenyl]ethanamide · in 1 record
- BWF · (2S)-2-[(Z)-1,3-bis(oxidanyl)-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid · in 1 record
- BWL · (2S)-2-[(Z)-3-[2-(diethylamino)ethyl-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]amino]-1-oxidanyl-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid · in 1 record
- CA · Calcium ion · in 1 record
- VQ7 · 6-[1,1-bis(oxidanylidene)-1,4-thiazinan-4-yl]-4-[[4-[4-chloranyl-3-(trifluoromethyl)phenoxy]-3,5-bis(fluoranyl)phenyl]methoxy]-1-methyl-pyrimidin-2-one · in 1 record
Elsewhere
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