UniProt Q12797
Aspartyl/asparaginyl beta-hydroxylase (Q12797)
Aspartyl/asparaginyl beta-hydroxylase (UniProt Q12797), EC 1.14.11.16: 35 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q12797
- Protein
- Aspartyl/asparaginyl beta-hydroxylase
- EC
- 1.14.11.16
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 32 · 9 records with a druggable one
Structures
36 records of Q12797 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5APA | Crystal structure of human aspartate beta-hydroxylase isoform a | x-ray diffraction | A | — | — |
| 5APA | Crystal structure of human aspartate beta-hydroxylase isoform a | x-ray diffraction | A | — | — |
| 5JQY | Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese… | x-ray diffraction | A | MN, OGA | 5 (best 0.73) |
| 5JQY | ASPARTYL/ASPARAGINYL beta-hydroxylase (ASPH)OXYGENASE and tpr domains in complex with manganese… | x-ray diffraction | A | — | — |
| 5JTC | Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese… | x-ray diffraction | A | MN, PD2, BR | — |
| 5JTC | ASPARTYL/ASPARAGINYL beta-hydroxylase (ASPH)OXYGENASE and tpr domains in complex with manganese… | — | — | — | |
| 5JZ6 | Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese and… | x-ray diffraction | A | MN, LMR | 1 (best 0.64) |
| 5JZ6 | ASPARTYL/ASPARAGINYL beta-hydroxylase (ASPH)OXYGENASE and tpr domains in complex with manganese and… | x-ray diffraction | A | — | — |
| 5JZ8 | ASPARTYL/ASPARAGINYL beta-hydroxylase (ASPH)OXYGENASE and tpr domains in complex with manganese… | x-ray diffraction | A | — | — |
| 5JZA | ASPARTYL/ASPARAGINYL beta-hydroxylase (ASPH)OXYGENASE and tpr domains in complex with manganese and… | x-ray diffraction | A | — | — |
| 5JZU | ASPARTYL/ASPARAGINYL beta-hydroxylase (ASPH)OXYGENASE and tpr domains in complex with manganese… | x-ray diffraction | A | — | — |
| 6Q9F | Aspartyl/Asparaginyl beta-hydroxylase (AspH) H679A in complex with Mn, NOG and Factor X peptide… | x-ray diffraction | A | MN, OGA | — |
| 6Q9F | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) H679A in complex with mn, nog and factor X peptide… | x-ray diffraction | A | MN, OGA | — |
| 6Q9I | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) H679A in complex with factor X peptide fragment… | x-ray diffraction | A | — | — |
| 6QA5 | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) H679A in the apo form | x-ray diffraction | A | — | — |
| 6RK9 | ASPARTYL/ASPARAGINYL beta-hydroxylase (ASPH)OXYGENASE and tpr domains in complex with manganese… | x-ray diffraction | A, B | MN, OGA | — |
| 6YYU | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) oxygenase and tpr domains in complex with manganese… | x-ray diffraction | A | MN, AKG | — |
| 6YYV | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) oxygenase and tpr domains in complex with manganese… | x-ray diffraction | A | MN, Q1Z | — |
| 6YYW | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese… | x-ray diffraction | A | MN, AKG | — |
| 6YYW | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) oxygenase and tpr domains in complex with manganese… | x-ray diffraction | A | MN, AKG | — |
| 6YYX | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) oxygenase and tpr domains in complex with manganese… | x-ray diffraction | A | MN, Q1Z | — |
| 6YYY | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) oxygenase and tpr domains in complex with manganese… | x-ray diffraction | A | MN, Q1W | — |
| 6Z6Q | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) oxygenase and tpr domains in complex with manganese… | x-ray diffraction | A | MN, QA8 | — |
| 6Z6R | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese… | x-ray diffraction | A | MN, BR, UQK | 4 (best 0.74) |
| 6Z6R | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) oxygenase and tpr domains in complex with manganese… | x-ray diffraction | A | MN, BR | — |
| 7BMI | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) oxygenase and tpr domains in complex with manganese… | x-ray diffraction | A | MN, U4B | — |
| 7BMJ | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) oxygenase and tpr domains in complex with manganese… | x-ray diffraction | A, C | MN, U4Q | — |
| 7E6J | Aspartyl/Asparaginyl beta-hydroxylase (AspH) H725A in complex with Factor X peptide fragment… | x-ray diffraction | A | — | — |
| 7E6J | ASPARTYL/ASPARAGINYL beta-hydroxylase (asph) H725A in complex with factor X peptide fragment… | x-ray diffraction | A | — | — |
| 7YBA | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with… | x-ray diffraction | A | MN, IO9 | 2 (best 0.64) |
| 7YBB | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with… | x-ray diffraction | A | MN, IO9 | 4 (best 0.54) |
| 7YBC | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with… | x-ray diffraction | A | MN, IOW | 5 (best 0.73) |
| 8RE5 | Aspartyl/Asparaginyl beta-hydroxylase (AspH) R735Q variant in complex with Mn, 2-oxosuberate and a… | x-ray diffraction | A | YQX, MN, CL | 4 (best 0.75) |
| 8RE7 | Aspartyl/Asparaginyl beta-hydroxylase (AspH) R735W variant in complex with Mn, 2-oxoglutarate and a… | x-ray diffraction | A | AKG, MN | 4 (best 0.73) |
| 8RE8 | Aspartyl/Asparaginyl beta-hydroxylase (AspH) R688Q variant in complex with Mn… | x-ray diffraction | A | Q1Z, MN, CL | 3 (best 0.52) |
| Q12797 | AlphaFold monomer V2.0 prediction for ASPARTYL/ASPARAGINYL beta- hydroxylase (Q12797) | predicted | A | — | — |
Ligands
- MN · Manganese (II) ion · in 23 records
- AKG · 2-oxoglutaric acid · in 4 records
- OGA · N-oxalylglycine · in 4 records
- BR · Bromide ion · in 3 records
- Q1Z · (3~{R})-3-methyl-2-oxidanylidene-pentanedioic acid · in 3 records
- CL · Chloride ion · in 2 records
- IO9 · (2~{R})-2-oxidanyl-4-oxidanylidene-pentanedioic acid · in 2 records
- IOW · (2~{S})-2-methyl-2-oxidanyl-4-oxidanylidene-pentanedioic acid · in 1 record
- LMR · (2S)-2-hydroxybutanedioic acid · in 1 record
- PD2 · Pyridine-2,4-dicarboxylic acid · in 1 record
- Q1W · 2,2-dimethyl-4-oxidanylidene-pentanedioic acid · in 1 record
- QA8 · (3~{R})-3-ethyl-2-oxidanylidene-pentanedioic acid · in 1 record
- U4B · 3-fluoranylpyridine-2,4-dicarboxylic acid · in 1 record
- U4Q · 5-fluoranylpyridine-2,4-dicarboxylic acid · in 1 record
- UQK · N-oxalyl-alpha-methylalanine · in 1 record
- YQX · 2-oxidanylideneoctanedioic acid · in 1 record
Experiment against prediction
- 8RE8 chain A against the predicted model Q12797: TM-score 1.00, RMSD 0.46 Å
- 7E6J chain A against the predicted model Q12797: TM-score 1.00, RMSD 0.49 Å
- 7E6J chain A against the predicted model Q12797: TM-score 1.00, RMSD 0.49 Å
- 7YBC chain A against the predicted model Q12797: TM-score 1.00, RMSD 0.51 Å
- 6YYX chain A against the predicted model Q12797: TM-score 0.99, RMSD 0.53 Å
- 8RE5 chain A against the predicted model Q12797: TM-score 0.99, RMSD 0.54 Å
- 7YBB chain A against the predicted model Q12797: TM-score 0.99, RMSD 0.55 Å
- 6YYY chain A against the predicted model Q12797: TM-score 0.99, RMSD 0.59 Å
- 5JQY chain A against the predicted model Q12797: TM-score 0.99, RMSD 0.59 Å
- 5JQY chain A against the predicted model Q12797: TM-score 0.99, RMSD 0.59 Å
Elsewhere
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