UniProt Q08689
N-terminal acetyltransferase A complex subunit NAT5 (Q08689)
N-terminal acetyltransferase A complex subunit NAT5 (UniProt Q08689), EC 2.3.1.-, 2.3.1.258: 11 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 40 pockets. Binding sites, druggability and experiment…
- UniProt
- Q08689
- Protein
- N-terminal acetyltransferase A complex subunit NAT5
- EC
- 2.3.1.-, 2.3.1.258
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 40 · 11 records with a druggable one
Structures
12 records of Q08689 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XNH | Crystal structure of yeast N-terminal acetyltransferase NatE (IP6) in complex with a bisubstrate | x-ray diffraction | C | ACO, CMC | 4 (best 0.85) |
| 4XNH | Crystal structure of yeast N-terminal acetyltransferase nate (IP6) in complex with a bisubstrate | x-ray diffraction | C | ACO, CMC | 4 (best 0.85) |
| 4XPD | Crystal structure of yeast N-terminal acetyltransferase NatE (ppGpp) in complex with a bisubstrate | x-ray diffraction | C | ACO, CMC | 2 (best 0.86) |
| 4XPD | Crystal structure of yeast N-terminal acetyltransferase nate (ppgpp) in complex with a bisubstrate | x-ray diffraction | C | ACO, CMC | 2 (best 0.86) |
| 4Y49 | Crystal structure of yeast N-terminal acetyltransferase (ppGpp) NatE in complex with a bisubstrate | x-ray diffraction | C, I, O | ACO | 7 (best 0.83) |
| 4Y49 | Crystal structure of yeast N-terminal acetyltransferase (ppgpp) nate in complex with a bisubstrate | x-ray diffraction | C, I, O | ACO | 7 (best 0.83) |
| 6HD5 | Cryo-EM structure of the ribosome-NatA complex | electron microscopy | v | — | 2 (best 0.84) |
| 6HD5 | Cryo-EM structure of the ribosome-nata complex | electron microscopy | v | — | 2 (best 0.84) |
| 6HD7 | Cryo-EM structure of the ribosome-NatA complex | electron microscopy | v | — | — |
| 6O07 | Structure and mechanism of acetylation by the N-terminal dual enzyme NatA/Naa50 complex | x-ray diffraction | C | CL, ACO | 4 (best 0.73) |
| 6O07 | Structure and mechanism of acetylation by the N-terminal dual enzyme NATA/NAA50 complex | x-ray diffraction | C | CL, ACO | 4 (best 0.73) |
| Q08689 | AlphaFold monomer V2.0 prediction for N-alpha-acetyltransferase NAT5 (Q08689) | predicted | A | — | 2 (best 0.67) |
Ligands
Experiment against prediction
- 4XPD chain C against the predicted model Q08689: TM-score 0.98, RMSD 0.83 Å
- 4XPD chain C against the predicted model Q08689: TM-score 0.98, RMSD 0.83 Å
- 4XNH chain C against the predicted model Q08689: TM-score 0.97, RMSD 1.00 Å
- 4XNH chain C against the predicted model Q08689: TM-score 0.97, RMSD 1.00 Å
- 6O07 chain C against the predicted model Q08689: TM-score 0.96, RMSD 0.97 Å
- 6O07 chain C against the predicted model Q08689: TM-score 0.96, RMSD 0.97 Å
- 4Y49 chain C against the predicted model Q08689: TM-score 0.95, RMSD 1.27 Å
- 4Y49 chain C against the predicted model Q08689: TM-score 0.95, RMSD 1.27 Å
- 4Y49 chain I against the predicted model Q08689: TM-score 0.94, RMSD 1.25 Å
- 4Y49 chain I against the predicted model Q08689: TM-score 0.94, RMSD 1.25 Å
Elsewhere
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