UniProt Q08649
Histone acetyltransferase ESA1 (Q08649)
Histone acetyltransferase ESA1 (UniProt Q08649), EC 2.3.1.48: 27 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 63 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q08649
- Protein
- Histone acetyltransferase ESA1
- EC
- 2.3.1.48
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 63 · 4 records with a druggable one
Structures
28 records of Q08649 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FY7 | Crystal structure of yeast ESA1 histone acetyltransferase domain complexed with coenzyme a | x-ray diffraction | A | — | — |
| 1FY7 | Crystal structure of yeast ESA1 histone acetyltransferase domain complexed with coenzyme a | x-ray diffraction | A | — | — |
| 1MJ9 | Crystal structure of yeast Esa1(C304S) mutant complexed with Coenzyme A | x-ray diffraction | A | — | — |
| 1MJ9 | Crystal structure of yeast ESA1(C304S) mutant complexed with coenzyme a | x-ray diffraction | A | — | — |
| 1MJA | Crystal structure of yeast Esa1 histone acetyltransferase domain complexed with acetyl coenzyme A | x-ray diffraction | A | — | — |
| 1MJA | Crystal structure of yeast ESA1 histone acetyltransferase domain complexed with acetyl coenzyme a | x-ray diffraction | A | — | — |
| 1MJB | Crystal structure of yeast Esa1 histone acetyltransferase E338Q mutant complexed with acetyl… | x-ray diffraction | A | — | — |
| 1MJB | Crystal structure of yeast ESA1 histone acetyltransferase E338Q mutant complexed with acetyl… | x-ray diffraction | A | — | — |
| 2RNZ | Solution structure of the presumed chromodomain of the yeast histone acetyltransferase, Esa1 | solution nmr | A | — | — |
| 2RNZ | Solution structure of the presumed chromodomain of the yeast histone acetyltransferase, ESA1 | solution nmr | A | — | — |
| 2RO0 | Solution structure of the knotted tudor domain of the yeast histone acetyltransferase, Esa1 | solution nmr | A | — | — |
| 2RO0 | Solution structure of the knotted tudor domain of the yeast histone acetyltransferase, ESA1 | solution nmr | A | — | — |
| 3TO6 | Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor | x-ray diffraction | A | — | — |
| 3TO6 | Crystal structure of yeast ESA1 hat domain complexed with H4K16COA bisubstrate inhibitor | x-ray diffraction | A | — | — |
| 3TO7 | Crystal structure of yeast Esa1 HAT domain bound to coenzyme A with active site lysine acetylated | x-ray diffraction | A | — | — |
| 3TO7 | Crystal structure of yeast ESA1 hat domain bound to coenzyme a with active site lysine acetylated | x-ray diffraction | A | — | — |
| 3TO9 | Crystal structure of yeast Esa1 E338Q HAT domain bound to coenzyme A with active site lysine… | x-ray diffraction | A | — | — |
| 3TO9 | Crystal structure of yeast ESA1 E338Q hat domain bound to coenzyme a with active site lysine… | x-ray diffraction | A | — | — |
| 5J9Q | Crystal structure of the NuA4 core complex | x-ray diffraction | E, A, I | — | 16 (best 0.83) |
| 5J9Q | Crystal structure of the NUA4 core complex | x-ray diffraction | E, A, I | — | — |
| 5J9T | Crystal structure of the NuA4 core complex | x-ray diffraction | E, A, I | — | 14 (best 0.79) |
| 5J9T | Crystal structure of the NUA4 core complex | x-ray diffraction | E, A, I | — | — |
| 5J9U | Crystal structure of the NuA4 core complex | x-ray diffraction | E, A, I | — | 18 (best 0.81) |
| 5J9U | Crystal structure of the NUA4 core complex | x-ray diffraction | E, A, I | — | — |
| 5J9W | Crystal structure of the NuA4 core complex | x-ray diffraction | E, A, I | ACO | 15 (best 0.81) |
| 5J9W | Crystal structure of the NUA4 core complex | x-ray diffraction | E, A, I | — | — |
| 7VVZ | NUA4 bound to the nucleosome | electron microscopy | P | CMC | — |
| Q08649 | AlphaFold monomer V2.0 prediction for histone acetyltransferase ESA1 (Q08649) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5J9W chain I against the predicted model Q08649: TM-score 0.98, RMSD 0.99 Å
- 5J9W chain I against the predicted model Q08649: TM-score 0.98, RMSD 0.99 Å
- 5J9W chain E against the predicted model Q08649: TM-score 0.98, RMSD 1.00 Å
- 5J9W chain E against the predicted model Q08649: TM-score 0.98, RMSD 1.00 Å
- 5J9T chain E against the predicted model Q08649: TM-score 0.98, RMSD 1.02 Å
- 5J9T chain E against the predicted model Q08649: TM-score 0.98, RMSD 1.02 Å
- 5J9T chain A against the predicted model Q08649: TM-score 0.98, RMSD 1.08 Å
- 5J9T chain A against the predicted model Q08649: TM-score 0.98, RMSD 1.08 Å
- 5J9W chain A against the predicted model Q08649: TM-score 0.98, RMSD 1.09 Å
- 5J9W chain A against the predicted model Q08649: TM-score 0.98, RMSD 1.09 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.