UniProt Q06528
Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB (Q06528)
Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB (UniProt Q06528), EC 2.1.1.-, 2.1.1.292: 23 experimental structures and 1 predicted model on GenesisL1, 10…
- UniProt
- Q06528
- Protein
- Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing…
- EC
- 2.1.1.-, 2.1.1.292, 4.1.1.-
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 80 · 10 records with a druggable one
Structures
24 records of Q06528 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TW2 | Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with… | x-ray diffraction | A, B | SAH, ERT | 7 (best 0.86) |
| 1TW2 | Crystal structure of carminomycin-4-O-methyltransferase (dnrk) in complex with… | x-ray diffraction | A, B | — | — |
| 1TW3 | Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with… | x-ray diffraction | A, B | SAH, ERT | 7 (best 0.86) |
| 1TW3 | Crystal structure of carminomycin-4-O-methyltransferase (dnrk) in complex with… | x-ray diffraction | A, B | — | — |
| 4WXH | Carminomycin-4-O-methyltransferase (DnrK) variant (298Ser insert) in complex with… | x-ray diffraction | A, B | — | — |
| 4WXH | Carminomycin-4-O-methyltransferase (dnrk) variant (298SER insert) in complex with… | x-ray diffraction | A, B | — | — |
| 5EEG | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with tetrazole-SAH | x-ray diffraction | A, B | S8M | — |
| 5EEG | Crystal structure of carminomycin-4-O-methyltransferase dnrk in complex with tetrazole-sah | x-ray diffraction | A, B | — | — |
| 5EEH | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and… | x-ray diffraction | A, B, C | SAH, P9P, SO4 | 11 (best 0.83) |
| 5EEH | Crystal structure of carminomycin-4-O-methyltransferase dnrk in complex with sah and… | x-ray diffraction | A, B, C | — | — |
| 5JR3 | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and… | x-ray diffraction | A, B, C | SAH, 4MU, SO4 | 10 (best 0.89) |
| 5JR3 | Crystal structure of carminomycin-4-O-methyltransferase dnrk in complex with sah and… | x-ray diffraction | A, B, C | — | — |
| 7OWB | Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-hydroxylase CalMB | x-ray diffraction | A | 3VL, SAH | 3 (best 0.80) |
| 7OWB | Chimeric carminomycin-4-O-methyltransferase (dnrk) with a region from 10-hydroxylase calmb | x-ray diffraction | A | 3VL | — |
| 7OY1 | DnrK mutant RTCR | x-ray diffraction | A, B | SAH, 3VL | 6 (best 0.85) |
| 7OY1 | Dnrk mutant rtcr | x-ray diffraction | A, B | 3VL | — |
| 7PGA | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and… | x-ray diffraction | A, B, C, D | SAH, VAK | 12 (best 0.84) |
| 7PGA | Chimeric carminomycin-4-O-methyltransferase (dnrk) with regions from 10-hydroxylase rdmb and… | x-ray diffraction | A, B, C, D | VAK | — |
| 7PGJ | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-decarboxylate TamK and… | x-ray diffraction | A | SAH, ZBX | 2 (best 0.77) |
| 7PGJ | Chimeric carminomycin-4-O-methyltransferase (dnrk) with regions from 10-decarboxylate tamk and… | x-ray diffraction | A | ZBX | — |
| 7PHD | Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-decarboxylase TamK | x-ray diffraction | A, B | SO4, SAM, 3VL | 6 (best 0.83) |
| 7PHE | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and… | x-ray diffraction | A, B | VAK | — |
| 7PHF | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and… | x-ray diffraction | A, B, C, D | SAH, VAK | 16 (best 0.85) |
| Q06528 | AlphaFold monomer V2.0 prediction for carminomycin 4-O-methyltransferase dnrk (Q06528) | predicted | A | — | — |
Ligands
- SAH · S-adenosyl-L-homocysteine · in 9 records
- 3VL · methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate · in 5 records
- VAK · methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate · in 4 records
- SO4 · Sulfate ion · in 3 records
- ERT · Methyl (4R)-2-ethyl-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-beta-D-ribo-hexopyranosyl]oxy}-1H,2H,3H,4H,6H,11H-tetracene-1-carboxylate · in 2 records
- ZBX · methyl (1R,2R,4S)-2-ethyl-7-methoxy-2,4,5-tris(oxidanyl)-6,11-bis(oxidanylidene)-3,4-dihydro-1H-tetracene-1-carboxylate · in 2 records
- 4MU · 7-hydroxy-4-methyl-2H-chromen-2-one · in 1 record
- P9P · 2-chloranyl-4-nitro-phenol · in 1 record
- S8M · (2~{R},3~{R},4~{S},5~{S})-2-(6-aminopurin-9-yl)-5-[[(3~{S})-3-azanyl-3-(1~{H}-1,2,3,4-tetrazol-5-yl)propyl]sulfanylmethyl]oxolane-3,4-diol · in 1 record
- SAM · S-adenosylmethionine · in 1 record
Experiment against prediction
- 7PHD chain A against the predicted model Q06528: TM-score 0.99, RMSD 0.72 Å
- 7OWB chain A against the predicted model Q06528: TM-score 0.98, RMSD 1.07 Å
- 5JR3 chain C against the predicted model Q06528: TM-score 0.98, RMSD 0.91 Å
- 5EEH chain C against the predicted model Q06528: TM-score 0.98, RMSD 0.96 Å
- 7OWB chain A against the predicted model Q06528: TM-score 0.98, RMSD 1.07 Å
- 5JR3 chain C against the predicted model Q06528: TM-score 0.98, RMSD 0.91 Å
- 5EEH chain C against the predicted model Q06528: TM-score 0.98, RMSD 0.96 Å
- 5EEG chain B against the predicted model Q06528: TM-score 0.98, RMSD 1.07 Å
- 5EEG chain B against the predicted model Q06528: TM-score 0.98, RMSD 1.07 Å
- 5EEG chain A against the predicted model Q06528: TM-score 0.98, RMSD 1.08 Å
Elsewhere
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