UniProt Q03LF7
CRISPR-associated endonuclease Cas9 1 (Q03LF7)
CRISPR-associated endonuclease Cas9 1 (UniProt Q03LF7), EC 3.1.-.-: 7 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q03LF7
- Protein
- CRISPR-associated endonuclease Cas9 1
- EC
- 3.1.-.-
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 20 · 1 record with a druggable one
Structures
8 records of Q03LF7 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6M0V | Crsytal structure of streptococcus thermophilus CAS9 in complex with the ggaa pam | x-ray diffraction | A | BA, MG | — |
| 6M0W | Crystal structure of streptococcus thermophilus CAS9 in complex with the agaa pam | x-ray diffraction | A | MG | — |
| 6M0X | Crystal structure of Streptococcus thermophilus Cas9 in complex with AGGA PAM | x-ray diffraction | A | BA, MG | 20 (best 0.85) |
| 6M0X | Crystal structure of streptococcus thermophilus CAS9 in complex with agga pam | x-ray diffraction | A | BA, MG | — |
| 6RJ9 | Cryo-EM structure of ST1CAS9-sgrna-TDNA20-ACRIIA6 monomeric assembly. | electron microscopy | C | — | — |
| 6RJA | Cryo-EM structure of St1Cas9-sgRNA-tDNA20-AcrIIA6 dimeric assembly. | electron microscopy | C, F | — | — |
| 6RJA | Cryo-EM structure of ST1CAS9-sgrna-TDNA20-ACRIIA6 dimeric assembly. | electron microscopy | C, F | — | — |
| Q03LF7 | AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS9 1 (Q03LF7) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6M0X chain A against the predicted model Q03LF7: TM-score 0.99, RMSD 0.86 Å
- 6M0X chain A against the predicted model Q03LF7: TM-score 0.99, RMSD 0.86 Å
- 6M0V chain A against the predicted model Q03LF7: TM-score 0.99, RMSD 0.85 Å
- 6M0W chain A against the predicted model Q03LF7: TM-score 0.99, RMSD 0.91 Å
- 6RJA chain F against the predicted model Q03LF7: TM-score 0.93, RMSD 2.83 Å
- 6RJA chain F against the predicted model Q03LF7: TM-score 0.93, RMSD 2.83 Å
- 6RJA chain C against the predicted model Q03LF7: TM-score 0.93, RMSD 2.83 Å
- 6RJA chain C against the predicted model Q03LF7: TM-score 0.93, RMSD 2.83 Å
- 6RJ9 chain C against the predicted model Q03LF7: TM-score 0.92, RMSD 3.00 Å
Elsewhere
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