UniProt Q02153
Guanylate cyclase soluble subunit beta-1 (Q02153)
Guanylate cyclase soluble subunit beta-1 (UniProt Q02153), EC 4.6.1.2: 21 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 58 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q02153
- Protein
- Guanylate cyclase soluble subunit beta-1
- EC
- 4.6.1.2
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 58 · 5 records with a druggable one
Structures
22 records of Q02153 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WZ1 | Structure of the catalytic domain of human soluble guanylate cyclase 1 beta 3. | x-ray diffraction | A, B | — | — |
| 2WZ1 | Structure of the catalytic domain of human soluble guanylate cyclase 1 beta 3. | x-ray diffraction | A, B | — | — |
| 3UVJ | Crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. | x-ray diffraction | B, D | — | — |
| 3UVJ | Crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. | x-ray diffraction | B, D | — | — |
| 4NI2 | Crystal structure of the heterodimeric catalytic domain of wild-type human soluble guanylate cyclase | x-ray diffraction | B | — | — |
| 4NI2 | Crystal structure of the heterodimeric catalytic domain of wild-type human soluble guanylate cyclase | x-ray diffraction | B | — | — |
| 5MNW | Solution structure of the cinaciguat bound human beta1 H-NOX. | solution nmr | A | Z90 | — |
| 5MNW | Solution structure of the cinaciguat bound human BETA1 H-nox. | solution nmr | A | Z90 | — |
| 6JT0 | Structure of human soluble guanylate cyclase in the unliganded state | electron microscopy | B | HEM | — |
| 6JT0 | Structure of human soluble guanylate cyclase in the unliganded state | electron microscopy | B | HEM | — |
| 6JT1 | Structure of human soluble guanylate cyclase in the heme oxidised state | electron microscopy | B | HEM | — |
| 6JT2 | Structure of human soluble guanylate cyclase in the no activated state | electron microscopy | B | G2P, HEM | — |
| 7D9R | Structure of huamn soluble guanylate cyclase in the riociguat and no- bound state | electron microscopy | B | G2P, HEM, GZO | — |
| 7D9S | Structure of huamn soluble guanylate cyclase in the YC1 and no-bound state | electron microscopy | B | YC1, HEM, G2P | — |
| 7D9T | Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state | electron microscopy | B | Z90 | 12 (best 0.85) |
| 7D9T | Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state | electron microscopy | B | Z90 | — |
| 7D9U | Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | electron microscopy | B | G2P, Z90 | 11 (best 0.86) |
| 7D9U | Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | electron microscopy | B | G2P, Z90 | — |
| 8HBE | Structure of human soluble guanylate cyclase in the inactive state at 3.1 angstrom | electron microscopy | B | HEM | 12 (best 0.81) |
| 8HBF | Structure of human soluble guanylate cyclase in the NO+Rio state at 3.1 angstrom | electron microscopy | B | G2P, HEM, GZO, NO | 10 (best 0.84) |
| 8HBH | Structure of human soluble guanylate cyclase in the NO-activated state at 3.1 angstrom | electron microscopy | B | G2P, HEM, NO | 13 (best 0.85) |
| Q02153 | AlphaFold monomer V2.0 prediction for guanylate cyclase soluble subunit beta-1 (Q02153) | predicted | A | — | — |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 9 records
- G2P · Phosphomethylphosphonic acid guanylate ester · in 7 records
- Z90 · 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl) benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid · in 6 records
- GZO · Methyl ~{N}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl) methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{N}-methyl-carbamate · in 2 records
- NO · Nitric oxide · in 2 records
- YC1 · [5-[1-(phenylmethyl)indazol-3-yl]furan-2-yl]methanol · in 1 record
Experiment against prediction
- 2WZ1 chain B against the predicted model Q02153: TM-score 0.98, RMSD 0.75 Å
- 2WZ1 chain B against the predicted model Q02153: TM-score 0.98, RMSD 0.75 Å
- 3UVJ chain B against the predicted model Q02153: TM-score 0.97, RMSD 0.91 Å
- 3UVJ chain B against the predicted model Q02153: TM-score 0.97, RMSD 0.91 Å
- 2WZ1 chain A against the predicted model Q02153: TM-score 0.97, RMSD 0.98 Å
- 2WZ1 chain A against the predicted model Q02153: TM-score 0.97, RMSD 0.98 Å
- 3UVJ chain D against the predicted model Q02153: TM-score 0.97, RMSD 0.95 Å
- 3UVJ chain D against the predicted model Q02153: TM-score 0.97, RMSD 0.95 Å
- 4NI2 chain B against the predicted model Q02153: TM-score 0.96, RMSD 1.12 Å
- 4NI2 chain B against the predicted model Q02153: TM-score 0.96, RMSD 1.12 Å
Elsewhere
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