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Ligand · GZO

GZO · Methyl ~{N}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl) methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{N}-methyl-carbamate

GZO, Methyl ~{N}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl) methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{N}-methyl-carbamate (C20 H19 F N8 O2, 422.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries).…

Component
GZO
Formula
C20 H19 F N8 O2
Class
ligand
Structures
3
PDB entries
2

Binding sites

GZO in 3 structures; the first of them:

  • 7D9R · Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state · GZO B702 · binds LEU425, ARG428, LEU429, TYR2, PHE4, HIS7, GLN36, VAL39 and 8 more
  • 8HBF · Structure of human soluble guanylate cyclase in the NO+Rio state at 3.1 angstrom · GZO B702 · binds LEU425, ARG428, LEU429, TYR2, PHE4, HIS7, VAL39, ARG40 and 7 more
  • 7D9R · Structure of huamn soluble guanylate cyclase in the riociguat and no- bound state · GZO B702 · binds LEU425, ARG428, LEU429, TYR2, PHE4, HIS7, GLN36, VAL39 and 8 more

Residues it binds most

TYR 3, ARG 3, LEU 3, PHE 3, CYS 3, GLU 3, HIS 3, SER 3, VAL 3, GLN 2 (residue and the binding sites it lines).

Found with

  • G2P · Phosphomethylphosphonic acid guanylate ester
  • HEM · Protoporphyrin IX containing Fe
  • MG · Magnesium ion
  • NO · Nitric oxide

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